Li Jian
Department of General Surgery, The Third Hospital of Mianyang Sichuan Mental Health Center, Mianyang, Sichuan 621000, China.
Gastroenterol Res Pract. 2020 Mar 2;2020:9512707. doi: 10.1155/2020/9512707. eCollection 2020.
Approximately 5.0% of gastric cancer (GC) patients are diagnosed before the age of 40 and are not candidates for screening programs in most countries and regions. The incidence of gastric cancer in young adults (GCYA) has declined over time in most countries except in the United States. Genetic alterations, environmental factors, and lifestyle may predispose some young adults to GC. According to molecular classifications, the cancer of most GCYA patients belongs to the genomically stable or microsatellite stable/epithelial-mesenchymal transition subtype, with the common genetic aberrations being mutations in . What characterizes GCYA are a higher prevalence in females, more aggressive tumor behaviors, diagnosis at advanced stages, fewer comorbidities and being better treatment candidates, and a similar or better survival outcome when compared with older patients. Considering the greater loss of life-years in younger patients, lowering the incidence of GC and diagnosing at a relatively early stage are the two most effective ways to decrease GC mortality. To achieve these goals, the low awareness of GCYA among general people, policy-makers, clinicians, and researchers should be changed.
约5.0%的胃癌患者在40岁之前被诊断出来，在大多数国家和地区，他们不符合筛查计划的条件。除美国外，大多数国家青年成人胃癌（GCYA）的发病率随时间有所下降。基因改变、环境因素和生活方式可能使一些青年成人易患胃癌。根据分子分类，大多数GCYA患者的癌症属于基因组稳定或微卫星稳定/上皮-间质转化亚型，常见的基因畸变是……GCYA的特征包括女性患病率较高、肿瘤行为更具侵袭性、晚期诊断、合并症较少且更适合接受治疗，与老年患者相比，其生存结果相似或更好。考虑到年轻患者生命年损失更大，降低胃癌发病率和相对早期诊断是降低胃癌死亡率的两种最有效方法。为实现这些目标，应改变普通民众、政策制定者、临床医生和研究人员对GCYA认识不足的状况。
