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Translational research: what is the value of experimental studies in comparison with clinical studies to help understand clinical problems?

作者信息

Cinelli Paolo, Rauen Katrin, Halvazishadeh Sascha, Pape Hans Christoph

机构信息

Department of Trauma, Universitaetsspital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Institute for Regenerative Medicine, IREM, University of Zurich, Campus Schlieren, Wagistrasse 12, Schlieren, 8952, Zurich, Switzerland.

出版信息

Eur J Trauma Emerg Surg. 2018 Oct;44(5):645-647. doi: 10.1007/s00068-018-1003-y.

DOI:10.1007/s00068-018-1003-y
PMID:30209526
Abstract
摘要

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本文引用的文献

1
Early local microcirculation is improved after intramedullary nailing in comparison to external fixation in a porcine model with a femur fracture.在猪股骨骨折模型中，与外固定相比，髓内钉固定后早期局部微循环得到改善。
Eur J Trauma Emerg Surg. 2018 Oct;44(5):689-696. doi: 10.1007/s00068-018-0991-y. Epub 2018 Aug 22.
2
Autologous cell-based therapy for treatment of large bone defects: from bench to bedside.用于治疗大骨缺损的自体细胞疗法：从实验台到临床应用
Eur J Trauma Emerg Surg. 2018 Oct;44(5):649-665. doi: 10.1007/s00068-018-0906-y. Epub 2018 Jan 19.
3
Are large fracture trials really possible? What we have learned from the randomized controlled damage control study?
大型骨折试验真的可行吗？我们从随机对照损伤控制研究中学到了什么？
Eur J Trauma Emerg Surg. 2018 Dec;44(6):917-925. doi: 10.1007/s00068-017-0891-6. Epub 2017 Dec 28.
4
Cardiac Depression in Pigs after Multiple Trauma - Characterization of Posttraumatic Structural and Functional Alterations.猪多发性创伤后的心脏抑制 - 创伤后结构和功能改变的特征。
Sci Rep. 2017 Dec 19;7(1):17861. doi: 10.1038/s41598-017-18088-1.
5
Using IL-6 concentrations in the first 24 h following trauma to predict immunological complications and mortality in trauma patients: a meta-analysis.利用创伤后最初24小时内的白细胞介素-6浓度预测创伤患者的免疫并发症和死亡率：一项荟萃分析。
Eur J Trauma Emerg Surg. 2018 Oct;44(5):679-687. doi: 10.1007/s00068-017-0880-9. Epub 2017 Nov 14.
6
Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model.在猪多创伤模型中，单核细胞上TLR2表达早期下降与其吞噬活性降低和成熟受损有关。
PLoS One. 2017 Nov 10;12(11):e0187404. doi: 10.1371/journal.pone.0187404. eCollection 2017.
7
Analysis of skeletal muscle microcirculation in a porcine polytrauma model with haemorrhagic shock.猪失血性休克多发伤模型骨骼肌微循环分析
J Orthop Res. 2018 May;36(5):1377-1382. doi: 10.1002/jor.23759. Epub 2018 Mar 14.
8
Hypothermia does not influence liver damage and function in a porcine polytrauma model.在猪多发伤模型中，体温过低并不影响肝损伤及肝功能。
Technol Health Care. 2018;26(2):209-221. doi: 10.3233/THC-171043.
9
Presentation Coagulopathy and Persistent Acidosis Predict Complications in Orthopaedic Trauma Patients.凝血障碍和持续性酸中毒预示骨科创伤患者的并发症
J Orthop Trauma. 2017 Dec;31(12):617-623. doi: 10.1097/BOT.0000000000000957.
10
Update on the role of endothelial cells in trauma.内皮细胞在创伤中作用的最新进展。
Eur J Trauma Emerg Surg. 2018 Oct;44(5):667-677. doi: 10.1007/s00068-017-0812-8. Epub 2017 Jul 3.