通过铑催化的分子内双 C-H 键活化合成咪唑并[2,1-a]异喹啉和苯并咪唑并[2,1-a]异喹啉。

Synthesis of imidazo and benzimidazo[2,1-a]isoquinolines by rhodium-catalyzed intramolecular double C-H bond activation.

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.

出版信息

Org Biomol Chem. 2013 Apr 14;11(14):2249-53. doi: 10.1039/c3ob27396b.

Abstract

The rhodium-catalyzed intramolecular direct arylation of imidazole and benzimidazole derivatives via double C-H bond activation is described. This approach provides new access to a wide range of imidazo and benzimidazo[2,1-a]isoquinoline derivatives in moderate to high yields. This reaction provides an alternative method to the known Pd-catalyzed intramolecular oxidative cross-coupling reactions.

摘要

铑催化的咪唑和苯并咪唑衍生物的分子内直接芳基化反应是通过双 C-H 键活化来实现的。这种方法为广泛的咪唑并和苯并咪唑[2,1-a]异喹啉衍生物提供了新的合成途径，产率中等至高产率。该反应为已知的 Pd 催化的分子内氧化交叉偶联反应提供了一种替代方法。