Divisions of Aging and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Am J Clin Nutr. 2013 Apr;97(4):698-705. doi: 10.3945/ajcn.112.050120. Epub 2013 Feb 27.
Although trans fatty acids (TFAs) may increase the risk of dyslipidemia and coronary artery disease (CAD), limited data are available on their association with heart failure (HF).
Our goal was to assess associations of plasma and dietary TFAs with HF and CAD.
We used a prospective, nested case-control design to select 788 incident HF cases and 788 matched controls from the Physicians' Health Study for biomarker analyses and a prospective cohort for the dietary analyses. Plasma fatty acids were assessed by using gas chromatography, and dietary intake was estimated by using a food-frequency questionnaire. Self-reported HF was ascertained by using annual follow-up questionnaires with validation in a subsample. We used conditional logistic (or Cox) regression to estimate multivariable-adjusted ORs (or HRs) for HF and CAD.
Multivariable-adjusted ORs (95% CIs) for HF across consecutive quintiles of plasma trans 18:2 (linoleic acid) fatty acids were 1.0 (reference), 1.10 (0.79, 1.54), 0.88 (0.62, 1.25), 0.71 (0.49, 1.02), and 0.67 (0.45, 0.98) (P-trend = 0.01). Each SD of plasma trans 18:2 was associated with a 22% lower risk of HF (95% CI: 6%, 36%). Plasma trans 16:1 and 18:1 were not associated with risk of HF (P > 0.05). Dietary trans fats were not associated with incident HF or CAD.
Our data are consistent with a lower risk of HF with higher concentrations of plasma trans 18:2 but not with trans 16:1 or trans 18:1 fatty acids in male physicians. Dietary TFAs were not related to incident HF or CAD.
尽管反式脂肪酸（TFAs）可能会增加血脂异常和冠心病（CAD）的风险，但关于其与心力衰竭（HF）的关系的相关数据有限。
我们的目标是评估血浆和饮食 TFAs 与 HF 和 CAD 的关联。
我们使用前瞻性、嵌套病例对照设计，从医师健康研究中选择 788 例新发 HF 病例和 788 例匹配对照进行生物标志物分析，并前瞻性队列进行饮食分析。通过气相色谱法评估血浆脂肪酸，通过食物频率问卷估计饮食摄入。HF 通过每年随访问卷确定，并在亚样本中进行验证。我们使用条件逻辑（或 Cox）回归来估计多变量调整后的 OR（或 HR）HF 和 CAD。
血浆反式 18:2（亚油酸）脂肪酸连续五分位数的 HF 多变量调整后 OR（95%CI）分别为 1.0（参考）、1.10（0.79，1.54）、0.88（0.62，1.25）、0.71（0.49，1.02）和 0.67（0.45，0.98）（P 趋势=0.01）。血浆反式 18:2 每增加一个标准差与 HF 风险降低 22%（95%CI：6%，36%）相关。血浆反式 16:1 和 18:1 与 HF 风险无关（P>0.05）。饮食反式脂肪与新发 HF 或 CAD 无关。
我们的数据表明，男性医生血浆反式 18:2 浓度较高与 HF 风险降低相关，但与反式 16:1 或反式 18:1 脂肪酸无关。饮食 TFAs 与新发 HF 或 CAD 无关。
