University of New England College of Osteopathic Medicine, Biddeford, ME, USA.
The Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA, USA.
Eur J Nutr. 2018 Dec;57(8):2937-2942. doi: 10.1007/s00394-017-1565-1. Epub 2017 Nov 1.
Although the association between monounsaturated fatty acids (MUFA) and risk factors for heart failure (HF) has been reported, it is unclear whether oleic acid, the predominant MUFA in olive oil, plays a role in the development of HF. Consequently, we sought to examine the relation of plasma phospholipid oleic acid with HF in a male cohort. In a secondary analysis, we examined the relation of the ratio of plasma monounsaturated-to-saturated fatty acids (MUFA: SFA) with HF.
This prospective nested case-control study was based on 788 incident HF cases and 788 controls from the Physicians' Health Study. Plasma phospholipid fatty acids were measured using gas chromatography and incident HF was self-reported via annual follow-up questionnaires and validated in a subsample using medical records.
The mean age was 58.7 years at blood collection. In a conditional logistic regression, multivariable adjusted-odds ratios (95% confidence interval) for HF across consecutive quartiles of oleic acid were 1.0 (reference), 1.10 (0.79-1.54), 1.02 (0.72-1.44), and 1.05 (0.72-1.54). For MUFA:SFA ratio, corresponding odds ratios (95% CI) for HF were 1.0 (ref), 1.12 (0.80-1.58), 1.19 (0.84-1.68), and 0.97 (0.66-1.42).
Our data do not lend support to an association between plasma phospholipid oleic acid or MUFA: SFA ratio and the risk of HF. These results warrant confirmation in the general population including women and other ethnic groups.
尽管单不饱和脂肪酸（MUFA）与心力衰竭（HF）的危险因素之间存在关联，但橄榄油中主要的 MUFA——油酸是否在 HF 的发展中起作用尚不清楚。因此，我们试图在男性队列中研究血浆磷脂油酸与 HF 的关系。在二次分析中，我们研究了血浆单不饱和脂肪酸与饱和脂肪酸（MUFA：SFA）比值与 HF 的关系。
这项前瞻性嵌套病例对照研究基于来自医师健康研究的 788 例新发 HF 病例和 788 例对照。使用气相色谱法测量血浆磷脂脂肪酸，通过年度随访问卷报告 HF 发病情况，并在亚样本中使用病历进行验证。
采血时的平均年龄为 58.7 岁。在条件逻辑回归中，连续四分位油酸的多变量校正比值比（95%置信区间）为 1.0（参考）、1.10（0.79-1.54）、1.02（0.72-1.44）和 1.05（0.72-1.54）。对于 MUFA：SFA 比值，HF 的相应比值比（95%CI）为 1.0（参考）、1.12（0.80-1.58）、1.19（0.84-1.68）和 0.97（0.66-1.42）。
我们的数据不支持血浆磷脂油酸或 MUFA：SFA 比值与 HF 风险之间的关联。这些结果需要在包括女性和其他种族群体在内的一般人群中得到证实。
