Pillay P, Van Thiel D H, Gavaler J S, Starzl T E
Department of Surgery, University of Pittsburgh, Pennsylvania.
Dig Dis Sci. 1990 Jun;35(6):686-9. doi: 10.1007/BF01540167.
The liver is recognized as a sex hormone-responsive organ. Gender-specific differences in liver function are known to exist. Recently, a higher failure rate for organs transplanted in adults from female donors to male recipients has been reported. This increased failure rate of livers obtained from adult females and transplanted into adult males is thought to occur, at least in part, as a result of intrinsic gender-specific differences in hepatocyte cell surface expression and to alterations in the hormonal milieu of the donor liver in the recipient. To determine whether the same graft-recipient gender-determined failure rates pertain in the pediatric liver transplant population, the outcome of 335 primary liver transplants performed in children at the University of Pittsburgh Medical Center was examined. No difference in transplant outcome was demonstrated in children based on the gender pairings between the donor and recipient whether or not variables such as the age, etiology of the liver disease, and the blood group of the recipient were included in the data analysis. Thus, in contrast, to the situation in adults, the gender of the donor does not influence the outcome of liver transplantation in children and should not be used as a criterion for donor selection. This difference between adults and children may be due, at least in part, to gender differences in hepatocyte phenotypic expression induced as a consequence of puberty.
肝脏被认为是一个对性激素有反应的器官。已知肝脏功能存在性别特异性差异。最近，有报道称成年女性供体向成年男性受体移植器官的失败率较高。成年女性供体的肝脏移植到成年男性体内失败率增加，至少部分原因被认为是肝细胞表面表达存在内在性别特异性差异，以及受体中供体肝脏激素环境的改变。为了确定相同的供受体性别决定的失败率是否适用于儿童肝移植人群，研究人员考察了匹兹堡大学医学中心为儿童进行的335例初次肝移植的结果。无论数据分析中是否纳入年龄、肝病病因、受体血型等变量，根据供体和受体的性别配对情况，儿童肝移植结果均未显示出差异。因此，与成人情况相反，供体性别不影响儿童肝移植结果，不应作为供体选择的标准。成人和儿童之间的这种差异至少部分可能是由于青春期导致的肝细胞表型表达的性别差异。
