Kahn D, Zeng Q H, Makowka L, Murase N, Nakajima Y, Eagon P K, Francavilla A, Starzl T E, Van Thiel D H
Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15261.
Hepatology. 1989 Nov;10(5):861-6. doi: 10.1002/hep.1840100519.
Mammalian liver is known to contain cytosolic receptors for both estrogens and androgens. Furthermore, certain mammalian hepatic functions are known to display a sexual dimorphism. However, in clinical liver transplantation, the sex of the donor is not taken into consideration in selection of the donor. In this study, the effect of liver transplantation on the estrogen and androgen receptor content of the liver was determined. Adult male and female rats were subjected to orthotopic liver transplantation, using donors from both the same and the opposite sex as the recipient. The animals were killed on the tenth postoperative day, and the livers were assayed to determine their cytosolic estrogen and androgen receptor content. Transplantation of a liver from a male donor into a male recipient, from a male donor into female recipient and from a female donor into a male recipient produced similar changes in the number of cytosolic estrogen and androgen receptors in hepatic cytosol. In all three situations, the estrogen receptor content in the cytosol of the transplanted liver was the same as that found in an unoperated male liver, and the cytosolic content of the androgen receptor was the same as that of an unoperated female liver. After transplantation of the liver from a female donor into a female recipient, the estrogen and androgen receptor content in the cytosol of the transplanted liver was the same as that of an unoperated female.(ABSTRACT TRUNCATED AT 250 WORDS)
已知哺乳动物肝脏含有雌激素和雄激素的胞质受体。此外，已知某些哺乳动物肝脏功能存在性别差异。然而，在临床肝移植中，供体的性别在供体选择中未被考虑。在本研究中，测定了肝移植对肝脏雌激素和雄激素受体含量的影响。成年雄性和雌性大鼠接受原位肝移植，供体与受体性别相同或相反。动物在术后第10天处死，测定肝脏以确定其胞质雌激素和雄激素受体含量。将雄性供体肝脏移植到雄性受体、雄性供体肝脏移植到雌性受体以及雌性供体肝脏移植到雄性受体，均可使肝胞质中胞质雌激素和雄激素受体数量产生相似变化。在所有这三种情况下，移植肝脏胞质中的雌激素受体含量与未手术的雄性肝脏中的相同，雄激素受体的胞质含量与未手术的雌性肝脏中的相同。将雌性供体肝脏移植到雌性受体后，移植肝脏胞质中的雌激素和雄激素受体含量与未手术的雌性肝脏中的相同。（摘要截短于250字）
