Boëns Benjamin, Azouz Mounir, Ouk Tan-Sothea, Zerrouki Rachida
Laboratoire de Chimie des Substances Naturelles, Limoges, France.
Nucleosides Nucleotides Nucleic Acids. 2013;32(2):69-80. doi: 10.1080/15257770.2013.763977.
This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.
本文涉及氮芥类似物（嘌呤碱衍生物）的合成。通过微波辐射实现了N - 9位的烷基化和6位的二乙醇胺固定。这些二羟基化中间体的氯化导致环化，生成带有氯乙基链的三环嘌呤碱类似物。最后，对所得化合物进行的MTT测定表明，其对四种不同的癌细胞系均无细胞毒性。
