Boëns Benjamin, Teste Karine, Hadj-Bouazza Amel, Ismaili Jihane, Zerrouki Rachida
Laboratoire de Chimie des Substances Naturelles EA1069, Faculté des Sciences et Techniques, Limoges, France.
Nucleosides Nucleotides Nucleic Acids. 2012;31(3):197-205. doi: 10.1080/15257770.2011.649330.
This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.
这项工作涉及基于胸腺嘧啶的新型氮芥衍生物的合成。为了将双（2-氯乙基）胺基团引入嘧啶碱基的4位，人们探索了许多策略，最终通过五步合成途径得到了所需的化合物。
