具有一个、两个或三个2-氯乙氨基片段的氮芥新类似物。与亲核试剂的反应。
The new analogues of nitrogen mustard with one, two or three 2-chloroethylamino fragments. Reactions with nucleophiles.
作者信息
Kolesińska Beata, Drozdowska Danuta, Kamiński Zbigniew J
机构信息
Institute of Organic Chemistry, Technical University of Łódź, 116 Zeromskiego St., 90-924 Łódź, Poland.
出版信息
Acta Pol Pharm. 2008 Nov-Dec;65(6):709-14.
PMID:19172853
Abstract
1,3,5-Triazines substituted with mono-, di, and tri-[4-(2-chloroethyl)piperazin-l-yl] groups gave products of substitution of chlorine atom when treated with ethanol, phenol, butylamine, toluidine,or thiophenol under mild reaction conditions.
摘要
被单、二和三-[4-(2-氯乙基)哌嗪-1-基]取代的1,3,5-三嗪在温和反应条件下用乙醇、苯酚、丁胺、甲苯胺或苯硫酚处理时会生成氯原子被取代的产物。
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