心脏衰老与胰岛素抵抗：胰岛素/胰岛素样生长因子（IGF）信号转导能否作为治疗靶点？
Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
机构信息
Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology & Genetics, 15 N 2030 E Bldg # 533 Rm. 3410B, Salt Lake City, Utah 84112, USA.
出版信息
Curr Pharm Des. 2013;19(32):5684-94. doi: 10.2174/1381612811319320004.
Abstract
Intrinsic cardiac aging is an independent risk factor for cardiovascular disease and is associated with structural and functional changes that impede cardiac responses to stress and to cardio-protective mechanisms. Although systemic insulin resistance and the associated risk factors exacerbate cardiac aging, cardiac-specific insulin resistance without confounding systemic alterations, could prevent cardiac aging. Thus, strategies aimed to reduce insulin/insulin-like growth factor (IGF) signaling in the heart prevent cardiac aging in lower organisms and in mammals but the mechanisms underlying this protection are not fully understood. In this review, we describe the impact of aging on the cardiovascular system and discuss the mounting evidence that reduced insulin/IGF signaling in the heart could alleviate age-associated alterations and preserve cardiac performance.
摘要
内在心脏衰老（intrinsic cardiac aging）是心血管疾病的一个独立风险因素，与阻碍心脏对压力和心脏保护机制做出反应的结构和功能变化有关。尽管系统性胰岛素抵抗（systemic insulin resistance）和相关的危险因素会加重心脏衰老，但不伴有系统性改变的心脏特异性胰岛素抵抗（cardiac-specific insulin resistance）可能会预防心脏衰老。因此，旨在降低心脏中胰岛素/胰岛素样生长因子（IGF）信号的策略可预防低等生物和哺乳动物的心脏衰老，但这种保护的机制尚不完全清楚。在这篇综述中，我们描述了衰老对心血管系统的影响，并讨论了越来越多的证据表明，降低心脏中的胰岛素/IGF 信号可以减轻与年龄相关的改变并维持心脏功能。
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