IGF-1 缺乏在心血管衰老中的新兴作用：最新进展。
The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.
机构信息
Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):599-610. doi: 10.1093/gerona/gls072. Epub 2012 Mar 26.
Abstract
This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging. Microvascular protection conferred by endocrine and paracrine IGF-1 signaling, its implications for the pathophysiology of cardiac failure and vascular cognitive impairment, and the role of impaired cellular stress resistance in cardiovascular aging considered here are based on emerging knowledge of the effects of IGF-1 on Nrf2-driven antioxidant response.
摘要
这篇综述重点关注胰岛素样生长因子 (IGF)-1 的心血管保护作用，提供了在先天性和成年期 IGF-1 缺乏的患者和动物模型中涉及心血管改变的分子机制的全景，并探讨了与年龄相关的 IGF-1 缺乏与心血管系统在衰老过程中发生的分子、细胞和功能变化之间的联系。内分泌和旁分泌 IGF-1 信号转导赋予的微血管保护作用，及其对心力衰竭和血管性认知障碍病理生理学的影响，以及细胞应激抵抗受损在心血管衰老中的作用，都是基于 IGF-1 对 Nrf2 驱动的抗氧化反应的影响的新认识。
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