Scheiermann Patrick, Pischke Soeren E
Crit Care. 2013 Mar 1;17(2):120. doi: 10.1186/cc12505.
Multidrug-resistant Gram-negative induced sepsis poses an increasing threat to the vulnerable intensive care patient. The study by Toufekoula and colleagues reports the serum and tissue concentration of malondialdehyde (MDA), the toxic end product of lipid peroxidation, during the course of experimental and human Gram-negative sepsis. The complementary results from this dual experimental and clinical approach argue for highly compartmentalized lipid peroxidation during sepsis. Establishing a correlation between MDA concentration and survival provides valuable insights into the pathophysiology of Gram-negative sepsis. Yet, further studies are needed to understand and establish MDA as a biomarker during sepsis aggravated by organ failure.
多重耐药革兰氏阴性菌引起的败血症对脆弱的重症监护患者构成了越来越大的威胁。图费库拉及其同事的研究报告了在实验性和人类革兰氏阴性菌败血症过程中，脂质过氧化的有毒终产物丙二醛（MDA）的血清和组织浓度。这种实验与临床相结合的互补性结果表明，败血症期间脂质过氧化具有高度的区域化。建立MDA浓度与生存率之间的相关性，为革兰氏阴性菌败血症的病理生理学提供了有价值的见解。然而，还需要进一步研究，以了解并将MDA确立为器官衰竭加重的败血症期间的生物标志物。
