Centre for DNA Fingerprinting and Diagnostics, Nampally, Andhra Pradesh, India.
Ann N Y Acad Sci. 2013 Apr;1283:97-101. doi: 10.1111/nyas.12070. Epub 2013 Feb 28.
Although the pathophysiological role of PE/PPE proteins of Mycobacterium tuberculosis is yet to be fully understood, recent evidence shows that these proteins play important roles in antigenic diversity, as well as in host-pathogen interactions and mycobacterial pathogenesis. Most of the PE/PPE proteins are highly expressed in pathogenic bacteria, pointing to their role in the pathogenesis of mycobacteria. Here, we provide an overview of our work in progress on a specific PPE protein, PPE2 (Rv0256c), which may inhibit nitric oxide (NO) production in activated macrophages. As NO and its by-products are considered to be toxic to bacilli, it is possible that the bacilli recruit Rv0256c in order to inhibit higher production of NO during infection.
虽然结核分枝杆菌的 PE/PPE 蛋白的病理生理作用尚未完全了解，但最近的证据表明，这些蛋白在抗原多样性以及宿主-病原体相互作用和分枝杆菌发病机制中发挥重要作用。大多数 PE/PPE 蛋白在致病性细菌中高度表达，这表明它们在分枝杆菌的发病机制中发挥作用。在这里，我们概述了我们正在进行的一项关于特定 PPE 蛋白 PPE2（Rv0256c）的工作，该蛋白可能抑制激活的巨噬细胞中一氧化氮（NO）的产生。由于 NO 及其副产物被认为对杆菌有毒，因此杆菌可能招募 Rv0256c 以抑制感染过程中 NO 的更高产生。
