Vijayendra H, Buggaveeti Greeshma, Parikh Bhavin, Sangitha R
Vijaya ENT Care Centre, Malleswaram, Bangalore, India.
Indian J Otolaryngol Head Neck Surg. 2012 Mar;64(1):1-4. doi: 10.1007/s12070-010-0049-x. Epub 2011 Apr 30.
The study purpose was to determine the efficacy of steroids, volume expanders and antivirals in the management of idiopathic sudden sensory neural hearing loss and to establish importance of early medical intervention. In this prospective study, thirty-four patients presenting with idiopathic sudden hearing loss of 30 db or more were enrolled in study group between 2005 and 2009. Patient variables as they related to recovery were studied and include patient age, time to onset of therapy, status of contralateral ear, presence of diabetes, severity of hearing loss, pattern of hearing loss in audiogram and presence of associated symptoms, (tinnitus, vertigo). Treatment protocol with intravenous hydrocortisone, intravenous dextran and oral anti-viral agent was followed. Pre-treatment and post-treatment pure tone average was analyzed. With combination therapy the overall improvement in pure tone threshold was seen in 27 patients (79.4%). A statistically significant association was found between the time at which medical intervention was started and hearing improvement. Early intervention in patients presenting before 3 days has given 77.8% complete type 1 recovery Idiopathic sudden sensory neural hearing loss is a medical emergency. It should not be misdiagnosed. Early detection and management with volume expanders, steroids and antivirals will improve the chances of complete recovery.
本研究的目的是确定类固醇、扩容剂和抗病毒药物在特发性突发性感音神经性听力损失治疗中的疗效,并确立早期医学干预的重要性。在这项前瞻性研究中,2005年至2009年间,34例出现30分贝或更高的特发性突发听力损失的患者被纳入研究组。研究了与恢复相关的患者变量,包括患者年龄、开始治疗的时间、对侧耳的状况、糖尿病的存在、听力损失的严重程度、听力图中的听力损失模式以及相关症状(耳鸣、眩晕)的存在。采用静脉注射氢化可的松、静脉注射右旋糖酐和口服抗病毒药物的治疗方案。分析了治疗前和治疗后的纯音平均值。联合治疗后,27例患者(79.4%)的纯音阈值总体有所改善。发现开始医学干预的时间与听力改善之间存在统计学上的显著关联。对发病3天内就诊的患者进行早期干预,1型完全恢复率为77.8%。特发性突发性感音神经性听力损失是一种医疗急症。不应误诊。早期发现并使用扩容剂、类固醇和抗病毒药物进行治疗将提高完全恢复的几率。