Department of Otolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, South Korea.
Am J Otolaryngol. 2011 Mar-Apr;32(2):91-5. doi: 10.1016/j.amjoto.2009.10.004. Epub 2009 Dec 22.
The purpose of this study was to evaluate the efficacy of combined therapy with steroid, carbogen inhalation, and lipoprostaglandin E(1) (lipo-PGE(1)) treatment and compare the results with other treatment modalities in patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
The study group consisted of 670 patients diagnosed with unilateral ISSNHL. Two hundred patients (DCP group) were treated with steroid, lipo-PGE(1) and carbogen inhalation combination therapy, 194 patients (DC group) with steroid and carbogen inhalation, and 276 patients (D group) with steroid medication only. The therapeutic effects of the treatment groups were evaluated 2 months after treatment, using pure tone averages. Siegel's criteria for hearing improvement were used for the assessments.
The overall recovery rate after treatment was 57.5%. For each group, the recovery rate was as follows: 67.0% in the DCP group, 52.6% in the DC group, and 53.9% in the D group. The DCP group had a significantly better improvement rate than the other 2 groups. In addition, the DCP treatment was better than the other 2 groups for patients: less than 50 years of age, with an initial hearing loss less than 90 dB HL, had treatment started within 1 week from the onset of hearing loss, had tinnitus or an ascending type audiogram, and/or had no vertigo.
Steroid, lipo-PGE(1), and carbogen inhalation therapy was more effective than the other treatment modalities studied for patients with ISSNHL.
本研究旨在评估类固醇、碳氧吸入和脂前列腺素 E1（lipo-PGE1）联合治疗的疗效，并将结果与其他治疗方法进行比较，以评估其在特发性突发性聋（ISSNHL）患者中的疗效。
本研究纳入了 670 例单侧 ISSNHL 患者。200 例患者（DCP 组）接受类固醇、脂前列腺素 E1 和碳氧吸入联合治疗，194 例患者（DC 组）接受类固醇和碳氧吸入治疗，276 例患者（D 组）仅接受类固醇治疗。2 个月后，采用纯音平均评估治疗组的疗效。采用 Siegel 听力改善标准进行评估。
治疗后总体恢复率为 57.5%。对于每个组，恢复率如下：DCP 组为 67.0%，DC 组为 52.6%，D 组为 53.9%。DCP 组的改善率明显高于其他 2 组。此外，对于以下患者，DCP 治疗优于其他 2 组：年龄小于 50 岁、初始听力损失小于 90dBHL、发病后 1 周内开始治疗、有耳鸣或听力曲线上升型、或无眩晕。
对于 ISSNHL 患者，类固醇、脂前列腺素 E1 和碳氧吸入治疗比其他治疗方法更有效。
