Everard C O, Bennett S
Leptospira Laboratory, Lower Collymore Rock, St. Michael, Barbados.
Eur J Epidemiol. 1990 Mar;6(1):40-4. doi: 10.1007/BF00155547.
Participants in a survey for leptospiral agglutinating antibodies undertaken in Trinidad, West Indies, in 1977-78, were further monitored for up to 5-and-a-half years. 52 individuals with a titre greater than or equal to 1:400 were matched for age, sex and occupation with seronegative subjects. They were re-bled twice (on average 2.38 and 4.84 years later), and changes of titre were noted. At the first follow-up, 78% of negative controls remained negative, and 22%, showed titre changes. Among the seropositive subjects, 47% showed a fall in titre, 38% showed no change, and in 15% the titre rose. New exposure rates between the original and first follow-up samples were 96/1,000 survey population per year in the controls, and 68/1,000 for the subjects with titres greater than or equal to 1:400. Between the first and second follow-up, 47% of the seropositive subjects lost titre, 40% showed no change, and 13% showed a rise in titre. These data demonstrate that although antibody titres may be maintained for a few years at the same level, or show a loss as is usually expected, about 8.3% of individuals in Trinidad may be infected/reinfected per year. The infection/reinfection rate is an important factor in the epidemiology of leptospirosis.
1977 - 1978年在西印度群岛特立尼达进行的一项关于钩端螺旋体凝集抗体的调查参与者，被进一步监测了长达5年半的时间。52名滴度大于或等于1:400的个体在年龄、性别和职业方面与血清阴性受试者进行了匹配。他们再次采血两次（平均分别在2.38年和4.84年后），并记录滴度变化。在第一次随访时，78%的阴性对照仍为阴性，22%出现滴度变化。在血清阳性受试者中，47%滴度下降，38%无变化，15%滴度上升。原始样本与第一次随访样本之间的新感染率在对照组中为每年每1000名调查人群96例，在滴度大于或等于1:400的受试者中为每年每1000名68例。在第一次和第二次随访之间，47%的血清阳性受试者滴度降低，40%无变化，13%滴度上升。这些数据表明，虽然抗体滴度可能在几年内维持在同一水平，或如通常预期的那样下降，但特立尼达每年约8.3%的个体可能会被感染/再次感染。感染/再次感染率是钩端螺旋体病流行病学中的一个重要因素。
