Murakami Shuji, Saito Haruhiro, Ohe Miki, Kondo Tetsuro, Oshita Fumihiro, Yamada Kouzo
Department of Thoracic Oncology, Kanagawa Cancer Center Hospital, Japan.
Intern Med. 2013;52(5):589-91. doi: 10.2169/internalmedicine.52.6632. Epub 2013 Mar 1.
Drug-induced vessel vasculitis is a rare complication of chemotherapy. In particular, few reports have investigated drug-induced large vessel vasculitis. We herein report the case of a 57-year-old woman with advanced lung adenocarcinoma who developed perinuclear anti-neutrophil cytoplastic antibodies (p-ANCA)-positive periaortitis induced by bevacizumab combination chemotherapy. With the increasing use of combination therapy with bevacizumab, the incidence of vascular complications will potentially increase. A noninfectious fever occurring during chemotherapy might be a sign of vasculitis; therefore, we must ensure that possible periaortitis is not overlooked.
药物性血管炎是化疗罕见的并发症。尤其是，关于药物性大血管炎的报道较少。我们在此报告一例57岁晚期肺腺癌女性患者，其在接受贝伐单抗联合化疗后发生了核周抗中性粒细胞胞浆抗体（p-ANCA）阳性的主动脉周炎。随着贝伐单抗联合治疗的使用增加，血管并发症的发生率可能会上升。化疗期间出现的非感染性发热可能是血管炎的迹象；因此，我们必须确保不忽视可能存在的主动脉周炎。
