Bouzerar Robert, Tekaya Issyan, Bouzerar Roger, Balédent Olivier
Laboratoire Physique des Systèmes Complexes, Département de Physique, Université de Picardie Jules Verne, 33 rue Saint-Leu, 80039 Amiens, France.
J Biol Phys. 2012 Mar;38(2):251-66. doi: 10.1007/s10867-011-9239-3. Epub 2011 Sep 29.
As brain ventricles lose their ability to regulate the cerebrospinal fluid (CSF) pressure, serious brain conditions collectively named hydrocephalus can appear. By modelling ventricular dynamics with the laws of physics, dynamical instabilities are evidenced, caused by either CSF transport dysregulations or abnormal properties of the elasticity of the ependyma. We show that these instabilities would lead, in most cases, to dilation of the ventricles, establishing a close connection to hydrocephalus, or in some other cases to a ventricular contraction as observed in the slit ventricle syndrome. Signs seem to indicate the possibility of phase transitions occurring as a result of these instabilities, which might have important clinical consequences, such as the inability to recover a healthy state. Even so, our dynamical approach could allow the development of a unified view of these complex intracranial conditions along with a classification that might be clinically relevant.
当脑室失去调节脑脊液（CSF）压力的能力时，就会出现统称为脑积水的严重脑部疾病。通过用物理定律对脑室动力学进行建模，发现了由脑脊液运输失调或室管膜弹性异常导致的动态不稳定性。我们表明，在大多数情况下，这些不稳定性会导致脑室扩张，与脑积水建立密切联系，或者在其他一些情况下导致如裂隙脑室综合征中观察到的脑室收缩。有迹象似乎表明，这些不稳定性可能导致相变，这可能会产生重要的临床后果，如无法恢复到健康状态。即便如此，我们的动力学方法可以使人们对这些复杂的颅内疾病形成统一的认识，并进行可能具有临床相关性的分类。
