Slozina N M, Narzullaeva M S, Nikitin A I
Genetika. 1990 Jan;26(1):154-7.
The influence of a single dose and of long-term alcohol administration on cytogenetic processes in the oocytes of Wistar white rats was studied. It is shown that a single dose of alcohol in preovulatory period when the oocytes are in the stage of diakinesismeiosis metaphase I significantly increases the rate of aneuploid gametes and dominant lethality. Analogous effect follows after long-term alcohol administration. Similarity of cytogenetic effects of acute and chronic alcohol intoxication suggests that both types of influence trigger common mechanism which results in chromosome abnormalities and, consequently, in embryonic death, i.e. dominant lethality. Taking into account that alcohol-like colchicine disturbs normal functioning of the spindle filaments, the appearance of pathology under alcohol intoxication may well be induced by disorders occurring in the stage of cell formation.
研究了单次剂量和长期给予酒精对Wistar大白鼠卵母细胞细胞遗传学过程的影响。结果表明，在排卵前期，当卵母细胞处于减数分裂中期双线期时，单次给予酒精会显著增加非整倍体配子的比率和显性致死率。长期给予酒精后也会出现类似的效果。急性和慢性酒精中毒的细胞遗传学效应相似，这表明两种类型的影响都触发了共同的机制，导致染色体异常，进而导致胚胎死亡，即显性致死率。考虑到酒精类似秋水仙碱会干扰纺锤丝的正常功能，酒精中毒时病理现象的出现很可能是由细胞形成阶段发生的紊乱所诱导的。
