Department of Neurology, CHU Reims, France.
Mult Scler. 2013 Aug;19(9):1222-5. doi: 10.1177/1352458513478674. Epub 2013 Feb 28.
Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system, usually occurring after a vaccination or infectious disease. It has been exceptionally described in transplanted patients. The pathophysiology remains incompletely understood. We report the clinical, biological and magnetic resonance imaging (MRI) presentation and evolution of two kidney-transplanted patients with ADEM associated with local Epstein-Barr virus (EBV) reactivation. ADEM may occur in transplanted patients with favorable evolution. Its pathophysiology is uncertain, and the implication of EBV is discussed.
急性播散性脑脊髓炎（ADEM）是一种罕见的中枢神经系统炎症性脱髓鞘疾病，通常发生在接种疫苗或传染病之后。它在移植患者中已有异常描述。其病理生理学仍不完全清楚。我们报告了 2 例肾移植后 ADEM 患者的临床、生物学和磁共振成像（MRI）表现及演变，与局部 Epstein-Barr 病毒（EBV）再激活有关。ADEM 可发生于移植后患者，其预后良好。其病理生理学尚不确定，讨论了 EBV 的作用。
