可溶性吡啶鎓型聚合物的抗菌活性
Antibacterial activity of soluble pyridinium-type polymers.
作者信息
Kawabata N, Nishiguchi M
机构信息
Department of Chemistry, Faculty of Engineering and Design, Kyoto Institute of Technology, Japan.
出版信息
Appl Environ Microbiol. 1988 Oct;54(10):2532-5. doi: 10.1128/aem.54.10.2532-2535.1988.
Abstract
Cross-linked poly(N-benzyl-4-vinylpyridinium halide) (designated insoluble BVP) was previously reported to capture bacterial cells alive by contact with them. The corresponding linear polymer poly(N-benzyl-4-vinylpyridinium salt) (designated soluble BVP) was found to exhibit antibacterial activity. This soluble pyridinium-type polymer showed strong antibacterial activity against gram-positive bacteria, whereas it was less active against gram-negative bacteria. The antibacterial activity of this cationic, polymeric disinfectant was considerably greater than that of the corresponding monomeric compound and was approximately equal to that of conventional disinfectants such as benzalkonium chloride and chlorohexidine.
摘要
交联聚（N-苄基-4-乙烯基卤化吡啶鎓）（称为不溶性BVP）此前有报道称可通过与细菌细胞接触来捕获活细菌细胞。发现相应的线性聚合物聚（N-苄基-4-乙烯基吡啶盐）（称为可溶性BVP）具有抗菌活性。这种可溶性吡啶鎓型聚合物对革兰氏阳性菌表现出很强的抗菌活性，而对革兰氏阴性菌的活性较弱。这种阳离子型聚合物消毒剂的抗菌活性大大高于相应的单体化合物，且与苯扎氯铵和氯己定等传统消毒剂大致相当。
相似文献
1
Antibacterial activity of soluble pyridinium-type polymers.可溶性吡啶鎓型聚合物的抗菌活性
Appl Environ Microbiol. 1988 Oct;54(10):2532-5. doi: 10.1128/aem.54.10.2532-2535.1988.
2
Polymer surfaces derivatized with poly(vinyl-N-hexylpyridinium) kill airborne and waterborne bacteria.用聚（乙烯基-N-己基吡啶鎓）衍生化的聚合物表面可杀死空气传播和水传播的细菌。
Biotechnol Bioeng. 2002 Aug 20;79(4):465-71. doi: 10.1002/bit.10299.
3
Pyridinium-Yne Click Polymerization: A Facile Strategy toward Functional Poly(Vinylpyridinium Salt)s with Multidrug-Resistant Bacteria Killing Ability.吡啶炔点击聚合：一种制备具有多药耐药菌杀灭能力的功能型聚乙烯基吡啶盐的简易策略。
Angew Chem Int Ed Engl. 2024 Jul 15;63(29):e202405030. doi: 10.1002/anie.202405030. Epub 2024 Jun 10.
4
Synthesis, structure and in vitro antibacterial activities of new hybrid disinfectants quaternary ammonium compounds: pyridinium and quinolinium stilbene benzenesulfonates.新型混合消毒剂季铵盐化合物：吡啶鎓和喹啉鎓二苯乙烯苯磺酸盐的合成、结构和体外抗菌活性。
Eur J Med Chem. 2010 Sep;45(9):4199-208. doi: 10.1016/j.ejmech.2010.06.014. Epub 2010 Jun 17.
5
Antimicrobial characteristic of insoluble alkylpyridinium iodide.不溶性烷基碘化吡啶鎓的抗菌特性
Appl Environ Microbiol. 1982 May;43(5):1041-50. doi: 10.1128/aem.43.5.1041-1050.1982.
6
Evaluation of the effectiveness of the potent bis-quaternary ammonium compound, 4,4'-(α,ω-hexametylenedithio) bis (1-octylpyridinium bromide) (4DTBP-6,8) on Pseudomonas aeruginosa.强效双季铵化合物4,4'-（α,ω-六亚甲基二硫）双（1-辛基吡啶溴化物）（4DTBP-6,8）对铜绿假单胞菌有效性的评估
J Appl Microbiol. 2017 Apr;122(4):893-899. doi: 10.1111/jam.13392. Epub 2017 Feb 15.
7
Antibacterial activity of MDPB polymer incorporated in dental resin.
J Dent. 1995 Jun;23(3):177-81. doi: 10.1016/0300-5712(95)93576-n.
8
[Antibacterial activity of disinfectant solutions containing quaternary ammonium compounds for the storage of surgical instruments].[含季铵化合物的消毒剂溶液用于手术器械储存的抗菌活性]
Arch Sci Med (Torino). 1982 Oct-Dec;139(4):491-7.
9
Designing surfaces that kill bacteria on contact.设计能在接触时杀死细菌的表面。
Proc Natl Acad Sci U S A. 2001 May 22;98(11):5981-5. doi: 10.1073/pnas.111143098. Epub 2001 May 15.
10
Comparative studies of two preparations containing chlorhexidine and cetylpyridinium chloride.两种含有氯己定和西吡氯铵制剂的对比研究。
Pharm Acta Helv. 1979;54(7-8):244-9.
引用本文的文献
1
Quaternary Ammonium Silica Nanoparticles for Antimicrobial Implantable Medical Devices: An In Vitro Study.用于抗菌可植入医疗器械的季铵化二氧化硅纳米颗粒：一项体外研究。
Life (Basel). 2024 Dec 12;14(12):1654. doi: 10.3390/life14121654.
2
Salt-Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties.具有抗菌和防污性能的盐响应型可切换嵌段共聚物刷
Macromol Biosci. 2025 Jan;25(1):e2400261. doi: 10.1002/mabi.202400261. Epub 2024 Nov 27.
3
Polypropylene-Rendered Antiviral by Three-Dimensionally Surface-Grafted Poly(-benzyl-4-vinylpyridinium bromide).三向表面接枝聚（-苄基-4-乙烯基吡啶溴化盐）的聚丙烯抗病毒。
ACS Appl Mater Interfaces. 2024 Feb 28;16(8):10590-10600. doi: 10.1021/acsami.3c15125. Epub 2024 Feb 11.
4
A Novel Cationic Polymer Surfactant for Regulation of the Rheological and Biocidal Properties of the Water-Based Drilling Muds.一种用于调节水基钻井液流变学和杀菌性能的新型阳离子聚合物表面活性剂。
Polymers (Basel). 2023 Jan 9;15(2):330. doi: 10.3390/polym15020330.
5
Construction and properties of the antibacterial epitaxial transition layer on a zirconia ceramic surface.氧化锆陶瓷表面抗菌外延过渡层的构建与性能
RSC Adv. 2021 Oct 29;11(55):34699-34709. doi: 10.1039/d1ra06496g. eCollection 2021 Oct 25.
6
Microhardness and Fluoride Release of Glass Ionomer Cement Modified with a Novel Al Complex to Enhance Its Antimicrobial Activity.用新型铝配合物改性以增强其抗菌活性的玻璃离子水门汀的显微硬度和氟释放
Int J Biomater. 2021 Oct 23;2021:1925388. doi: 10.1155/2021/1925388. eCollection 2021.
7
A novel bis(pyrazolyl)methane compound as a potential agent against Gram-positive bacteria.一种新型双（吡唑基）甲烷化合物作为对抗革兰氏阳性菌的潜在药物。
Sci Rep. 2021 Aug 11;11(1):16306. doi: 10.1038/s41598-021-95609-z.
8
Biocidal Polymers: Synthesis, Characterization and Antimicrobial Activity of Bis-Quaternary Onium Salts of Poly(aspartate--succinimide).杀生聚合物：聚（天冬氨酸-琥珀酰亚胺）双季铵盐的合成、表征及抗菌活性
Polymers (Basel). 2020 Dec 23;13(1):23. doi: 10.3390/polym13010023.
9
Fabrication of Bis-Quaternary Ammonium Salt as an Efficient Bactericidal Weapon Against and .双季铵盐作为对抗[具体细菌名称1]和[具体细菌名称2]的高效杀菌武器的制备
ACS Omega. 2018 Oct 31;3(10):14517-14525. doi: 10.1021/acsomega.8b01265.
10
Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions.基于宿主生物材料和微生物相互作用的生物稳定、抗降解和抗菌修复系统。
Dent Mater. 2019 Jan;35(1):36-52. doi: 10.1016/j.dental.2018.09.013. Epub 2018 Oct 6.
本文引用的文献
1
Removal of bacteria from water by adhesion to cross-linked poly(vinylpyridinium halide).通过与交联聚（卤化乙烯基吡啶）的粘附作用从水中去除细菌。
Appl Environ Microbiol. 1983 Jul;46(1):203-10. doi: 10.1128/aem.46.1.203-210.1983.
2
New polymeric biocides: synthesis and antibacterial activities of polycations with pendant biguanide groups.新型聚合物杀菌剂：含侧链双胍基团聚阳离子的合成及抗菌活性
Antimicrob Agents Chemother. 1984 Aug;26(2):139-44. doi: 10.1128/AAC.26.2.139.
Zotero 插件