血液睾酮水平：调节蜥蜴免疫反应性的一个季节依赖性因素。

Blood testosterone level: a season-dependent factor regulating immune reactivity in lizards.

作者信息

Saad A H, Khalek N A, el Ridi R

机构信息

Zoology Department, Faculty of Science, Cairo University, Egypt.

出版信息

Immunobiology. 1990 Feb;180(2-3):184-94. doi: 10.1016/S0171-2985(11)80327-X.

DOI:10.1016/S0171-2985(11)80327-X

PMID:2345015

Abstract

An attempt to study the interaction between testosterone (Ts) and the immune system of the lizard Chalcides ocellatus led to three major findings: 1) Endogenous serum Ts levels in both males and females peak in spring and are minimal during summer; 2) Injection of Ts in either male or female lizards induces significant depletion of lymphoid elements, reduction in serum antibody titers to rat erythrocytes and increase in skin allograft survival; 3) A distinct inverse correlation between endogenous serum Ts levels and lizard immunocompetence is observed from March to September. The data obtained strongly suggested that concentration of circulating Ts is a season-related factor that is critical in defining the immune profile of lizards.

摘要

一项关于研究睾酮（Ts）与眼斑沙蜥免疫系统之间相互作用的尝试得出了三个主要发现：1）雄性和雌性蜥蜴体内的内源性血清Ts水平在春季达到峰值，而在夏季降至最低；2）对雄性或雌性蜥蜴注射Ts会导致淋巴样细胞显著减少、对大鼠红细胞的血清抗体滴度降低以及皮肤同种异体移植存活时间延长；3）在3月至9月期间，观察到内源性血清Ts水平与蜥蜴免疫能力之间存在明显的负相关。所获得的数据有力地表明，循环中的Ts浓度是一个与季节相关的因素，对确定蜥蜴的免疫特征至关重要。