Saad A H, el Ridi R, el Deeb S, Soliman M A
Dev Comp Immunol. 1986 Spring;10(2):235-45. doi: 10.1016/0145-305x(86)90006-6.
Administration of a single injection of 1.0 mg/g body weight hydrocortisone acetate (HC) to adult lizards, Chalcides ocellatus in summer elicited a high and lasting rise in serum corticosterone and cortisol, peak levels being, however, in the physiologic ranges of 10 micrograms % (2 X 10(-7) M) and 40 micrograms % (1 X 10(-6) M), respectively. Elevation of serum corticosteroid (CS) concentrations by exogenous HC impaired the proliferative capacity of spleen cells in mixed leukocyte reaction (MLR) and significantly delayed skin allograft rejection. In vivo HC also abrogated the primary in vivo and in vitro immune responses of lizards to rat erythrocytes (RRBC). Reactivity to allogeneic cells in MLR, and antibody production against RRBC were, however, recovered when serum CS levels resumed normal, basal values i.e. at three weeks post-HC injection. These data indicate that rise in circulating CS induces severe immunosuppression in lizards.
在夏季，给成年眼斑沙蜥（Chalcides ocellatus）单次注射1.0毫克/克体重的醋酸氢化可的松（HC），会引发血清皮质酮和皮质醇的高水平且持久的升高，然而，峰值水平分别处于10微克%（2×10⁻⁷M）和40微克%（1×10⁻⁶M）的生理范围内。外源性HC引起的血清皮质类固醇（CS）浓度升高损害了混合淋巴细胞反应（MLR）中脾细胞的增殖能力，并显著延迟了皮肤同种异体移植排斥反应。体内HC还消除了蜥蜴对大鼠红细胞（RRBC）的原发性体内和体外免疫反应。然而，当血清CS水平恢复到正常基础值时，即HC注射后三周，MLR中对同种异体细胞的反应性以及针对RRBC的抗体产生得以恢复。这些数据表明，循环CS的升高会在蜥蜴中诱导严重的免疫抑制。
