K O Thejaswini, M S Roopakala, G Dayananda, S P Chandrakala, Kumar K M Prasanna
Assistant Professor, Department of Physiology, SSMC , Tumkur, India .
J Clin Diagn Res. 2013 Jan;7(1):46-50. doi: 10.7860/JCDR/2012/4854.2667. Epub 2012 Oct 14.
The Ankle-Brachial Index (ABI) objectively assesses the lower extremity arterial perfusion. A low ABI suggests atherosclerosis and Peripheral Arterial Disease (PAD). PAD is more common in individuals with type2 Diabetes mellitus (Type2 DM). Inflammatory markers are found to be associated with Type2 DM. But the association of the inflammatory markers with the atherosclerotic burden remains poorly defined.
To compare the ABI and the hsCRP in the Type 2 DM patients with those in the normal subjects and to study the association of serum hsCRP with ABI in the Type 2 DM patients and in normal subjects.
The subjects were 40 Type2 DM and 40 age, sex and BMI matched normal subjects who were aged between 45-60 yrs. The subjects were assigned to two different groups, Group1- the Type2 DM patients and Group2- the healthy controls. The serum hsCRP levels were determined by the turbidimetry method (BIOSYSTEMS) and the ABI values were determined by using the traditional continuous wave (CW) Doppler of NICOLET VERSALAB.
The data was analyzed by using the Student's t test (two tailed; independent) to find the significance of the study parameters between the two groups. Pearson's Correlation was used to find the correlation of serum hsCRP with the ABI in the two groups.
The ABI showed a significantly low value (P=0.035*) and the serum hsCRP showed a trend towards a significant increase (p = 0.069+) in the type2diabetics as compared to those in the normals. There was a significant negative correlation between ABI and hsCRP in the Type 2 DM patients (r=-0.560, p<0.001**). However, such correlation was not observed in the normal subjects.
As serum hsCRP is associated with ABI in the type2 DM patients, inflammation may play a role in the pathogenesis of atherosclerosis.
踝臂指数（ABI）可客观评估下肢动脉灌注情况。低ABI提示动脉粥样硬化和外周动脉疾病（PAD）。PAD在2型糖尿病（2型DM）患者中更为常见。炎症标志物与2型DM相关。但炎症标志物与动脉粥样硬化负担之间的关联仍不明确。
比较2型DM患者与正常受试者的ABI及超敏C反应蛋白（hsCRP），并研究2型DM患者及正常受试者血清hsCRP与ABI之间的关联。
研究对象为40例年龄在45至60岁之间的2型DM患者以及40例年龄、性别和体重指数相匹配的正常受试者。将受试者分为两组：1组为2型DM患者，2组为健康对照。采用比浊法（BIOSYSTEMS）测定血清hsCRP水平，使用NICOLET VERSALAB的传统连续波（CW）多普勒测定ABI值。
采用学生t检验（双侧；独立样本）分析数据，以确定两组研究参数之间的显著性差异。使用Pearson相关性分析来确定两组中血清hsCRP与ABI之间的相关性。
与正常受试者相比，2型糖尿病患者ABI值显著降低（P = 0.035*），血清hsCRP呈显著升高趋势（p = 0.069+）。2型DM患者中ABI与hsCRP存在显著负相关（r = -0.560，p <0.001**）。然而在正常受试者中未观察到这种相关性。
由于2型DM患者血清hsCRP与ABI相关联，炎症可能在动脉粥样硬化的发病机制中起作用。
