Spyra W J, Bell M R, Bahn R C, Zinsmeister A R, Ritman E L, Bove A A
Department of Physiology and Biophysics, Mayo Medical School, Rochester, Minn. 55905.
Invest Radiol. 1990 May;25(5):472-9. doi: 10.1097/00004424-199005000-00002.
The accuracy of the Dynamic Spatial Reconstructor (DSR) in the detection of moderate coronary artery stenoses was examined in 20 closed-chest dogs. Twenty-eight hollow plastic cylinders were embolized into the left coronary arteries and produced 25% to 56% reductions in arterial lumina diameter. For each dog, one three-dimensional (3-D) image of the heart was reconstructed from each DSR scan recorded during injection of contrast into the aortic root. Analysis involved blinded visual analysis by four independent observers of multiview projection images computed from the single 3-D image. Postmortem coronary angiograms of the isolated heart were considered definitive for location of the stenoses. Overall sensitivity of detection by DSR was 89% and specificity 81%. Sensitivity of detecting stenoses greater than or equal to 50% was 98%. Receiver operating characteristics (ROC) analysis showed that detection of stenoses in the left coronary arteries is of equal sensitivity and specificity.
在20只开胸犬中检测了动态空间重建仪（DSR）检测中度冠状动脉狭窄的准确性。将28个中空塑料圆柱体栓塞到左冠状动脉中，使动脉管腔直径减少25%至56%。对于每只犬，在向主动脉根部注射造影剂期间记录的每次DSR扫描中，重建一张心脏的三维（3-D）图像。分析包括由四名独立观察者对从单个3-D图像计算出的多视图投影图像进行盲法视觉分析。离体心脏的尸检冠状动脉造影被认为是确定狭窄位置的金标准。DSR检测的总体敏感性为89%，特异性为81%。检测大于或等于50%狭窄的敏感性为98%。受试者操作特征（ROC）分析表明，左冠状动脉狭窄的检测具有相同的敏感性和特异性。
