Briles E B, Tomasz A
J Gen Microbiol. 1975 Feb;86(2):267-74. doi: 10.1099/00221287-86-2-267.
The cell concentration and possible biological activities of the pneumococcal Forssman (F) antigen (membrane lipoteichoic acid) were examined in a number of physiological situations. In test tube cultures of pneumococci the concentration of the Forssman antigen per bacterium showed no significant fluctuations within a typical culture cycle. Purified F antigen had no effect on the activation of pneumococci to competence for genetic transformation, DNA mediated genetic transformation or adsorption of the pneumococcal phage Dp-1 to bacteria. Pneumococci grown in the presence of different amino alcohols (ethanolamine, N-monomethylethanolamine, or choline) exhibit differences with regard to both their ability to stimulate heterophile (haemolytic) antibody production in rabbits and in their ability to bind such antibodies. Choline-grown bacteria seem to cross-react with sheep red blood cells better than do the analogue-grown bacteria.
在多种生理情况下，对肺炎球菌福斯曼（F）抗原（膜脂磷壁酸）的细胞浓度及可能的生物学活性进行了检测。在肺炎球菌的试管培养中，每个细菌的福斯曼抗原浓度在典型培养周期内无显著波动。纯化的F抗原对肺炎球菌转化为感受态进行遗传转化、DNA介导的遗传转化或肺炎球菌噬菌体Dp - 1吸附到细菌上均无影响。在不同氨基醇（乙醇胺、N - 单甲基乙醇胺或胆碱）存在下生长的肺炎球菌，在刺激兔体内嗜异性（溶血）抗体产生的能力以及结合此类抗体的能力方面均表现出差异。胆碱培养的细菌似乎比类似物培养的细菌与绵羊红细胞的交叉反应更好。
