脂磷壁酸：肺炎球菌自溶素活性的特异性抑制剂。
Lipoteichoic acid: a specific inhibitor of autolysin activity in Pneumococcus.
作者信息
Höltje J V, Tomasz A
出版信息
Proc Natl Acad Sci U S A. 1975 May;72(5):1690-4. doi: 10.1073/pnas.72.5.1690.
Abstract
The choline-containing pneumococcal lipoteichoic acid (Forssman antigen) is a powerful inhibitor of the homologous autolytic enzyme, an N-acetylmuramyl-L-alanine amidase (EC 3.5.1.28, MUCOPEPTIDE AMIDOHYDROLASE). Low concentrations of deoxycholate can reverse the inhibition. Wall teichoic acid preparations are inactive at several hundred-fold higher concentrations. Activation of an inactive form of autolysin by in vitro incubation with choline-containing cell walls is also inhibited by lipoteichoic acid. Addition of lipoteichoic acid to the growth medium of pneumococcal cultures causes chain formation, resistance to stationary phase lysis, and penicillin tolerance. It is suggested that a physiological role of lipoteichoic acids may be in the in vivo control of autolysin activity.
摘要
含胆碱的肺炎球菌脂磷壁酸（福斯曼抗原）是同源自溶酶的强效抑制剂，该自溶酶为N - 乙酰胞壁酰 - L - 丙氨酸酰胺酶（EC 3.5.1.28，粘肽酰胺水解酶）。低浓度的脱氧胆酸盐可逆转这种抑制作用。壁磷壁酸制剂在几百倍高的浓度下无活性。脂磷壁酸也抑制了通过与含胆碱细胞壁进行体外孵育对无活性形式自溶素的激活。向肺炎球菌培养物的生长培养基中添加脂磷壁酸会导致链形成、对稳定期裂解的抗性以及对青霉素的耐受性。有人提出脂磷壁酸的生理作用可能在于体内对自溶素活性的控制。
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