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[长循环β-榄香烯脂质体的药代动力学]

[The pharmacokinetics of long-circulating beta-elemene liposomes].

作者信息

Zhang Bing-jiang, Li Wei-chao, Liu Xiao-ping

机构信息

Hospital of Wuhan University of Technology, Wuhan 430070, China.

出版信息

Zhong Yao Cai. 2012 Sep;35(9):1464-8.

PMID:23451504
Abstract

OBJECTIVE

To study the pharmacokinetics of long-circulating beta-elemene liposomes.

METHODS

Gas chromatography was established to determine the concentration of beta-elemene in plasma of rats.

RESULTS

The alpha, T(1/2beta), K12 and AUC of long-circulating beta-elemene liposomes groups were higher compared with those of the conventional liposomes,and the T(1/2alpha), Vc, CL, K10 of the latter were lower.

CONCLUSION

Long-circulating beta-elemene liposomes can prolong the duration of beta-elemene in the body and improve the efficacy of drugs.

摘要

目的

研究长循环β-榄香烯脂质体的药代动力学。

方法

建立气相色谱法测定大鼠血浆中β-榄香烯的浓度。

结果

长循环β-榄香烯脂质体组的α、T(1/2β)、K12和AUC较传统脂质体组更高，而后者的T(1/2α)、Vc、CL、K10更低。

结论

长循环β-榄香烯脂质体可延长β-榄香烯在体内的作用时间，提高药物疗效。

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