[长循环β-榄香烯脂质体的药代动力学]
[The pharmacokinetics of long-circulating beta-elemene liposomes].
作者信息
Zhang Bing-jiang, Li Wei-chao, Liu Xiao-ping
机构信息
Hospital of Wuhan University of Technology, Wuhan 430070, China.
出版信息
Zhong Yao Cai. 2012 Sep;35(9):1464-8.
OBJECTIVE
To study the pharmacokinetics of long-circulating beta-elemene liposomes.
METHODS
Gas chromatography was established to determine the concentration of beta-elemene in plasma of rats.
RESULTS
The alpha, T(1/2beta), K12 and AUC of long-circulating beta-elemene liposomes groups were higher compared with those of the conventional liposomes,and the T(1/2alpha), Vc, CL, K10 of the latter were lower.
CONCLUSION
Long-circulating beta-elemene liposomes can prolong the duration of beta-elemene in the body and improve the efficacy of drugs.
目的
研究长循环β-榄香烯脂质体的药代动力学。
方法
建立气相色谱法测定大鼠血浆中β-榄香烯的浓度。
结果
长循环β-榄香烯脂质体组的α、T(1/2β)、K12和AUC较传统脂质体组更高，而后者的T(1/2α)、Vc、CL、K10更低。
结论
长循环β-榄香烯脂质体可延长β-榄香烯在体内的作用时间，提高药物疗效。
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