Zhang Xiu-yu, Deng Ying-jie, Zhao Chun-jie, Wang Xiu-min, Li Zhe, Gao Xiao-fei
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhong Yao Cai. 2006 Feb;29(2):157-60.
To study the pharmacokinetics of PVP costed beta-elemente liposmes in rats.
Gas chromatography was established to determine the concentration of beta-elemene in plasma of rats after administered through i.g.
The pharmacokinetics parameters was: T(1/2) = 95.07 +/- 20.46 min, AUC = 348.72 +/- 32.49 microg x min/ml, Cmax = 4.39 +/- 0.33 microg/ml, Tmax = 60 min.
The bioavailability of PVP coated beta-elemene liposomes is 140.2 +/- 7.5% compared with conventional liposomes.
研究聚乙烯吡咯烷酮（PVP）包衣的β-榄香烯脂质体在大鼠体内的药代动力学。
建立气相色谱法测定大鼠经灌胃给药后血浆中β-榄香烯的浓度。
药代动力学参数为：T(1/2)=95.07±20.46分钟，AUC=348.72±32.49微克·分钟/毫升，Cmax=4.39±0.33微克/毫升，Tmax=60分钟。
与传统脂质体相比，PVP包衣的β-榄香烯脂质体的生物利用度为140.2±7.5%。
