Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Arch Pathol Lab Med. 2013 Mar;137(3):382-91. doi: 10.5858/arpa.2012-0202-RA.
Diagnosis and classification of lymphomas are based on the morphologic, immunologic, and genetic features that the lesional cells share with their normal B and T lymphocyte counterparts. Primary pulmonary lymphomas account for 0.3% of primary lung neoplasms and less than 0.5% of all lymphomas.
To describe and summarize the clinical and histopathologic features of the primary pulmonary lymphoma and secondary involvement of the lung by lymphoma.
Peer-reviewed published literature and personal experience.
Diagnosis of clonal lymphoid proliferations in the lung has evolved owing to the greater utility of molecular and flow cytometric analysis of tissue. Further studies are needed to best define the clinical and prognostic features, as well as search for targeted therapy for these patients with rare neoplasms.
淋巴瘤的诊断和分类基于病变细胞与其正常 B 和 T 淋巴细胞对应物共享的形态、免疫和遗传特征。原发性肺淋巴瘤占原发性肺肿瘤的 0.3%，占所有淋巴瘤的不到 0.5%。
描述和总结原发性肺淋巴瘤和淋巴瘤继发性肺累及的临床和组织病理学特征。
同行评议的已发表文献和个人经验。
由于对组织的分子和流式细胞术分析的更大实用性，肺克隆性淋巴增生的诊断已经发展。需要进一步的研究来最好地定义这些罕见肿瘤患者的临床和预后特征，并寻找针对这些患者的靶向治疗。
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