Department of Hygiene and Public Health, Osaka Medical College, Takatsuki, Osaka, Japan.
Geriatr Gerontol Int. 2013 Oct;13(4):958-63. doi: 10.1111/ggi.12037. Epub 2013 Mar 3.
The present study aimed to determine the association of sarcopenia, defined by muscle mass, muscle strength and physical performance, with functional disability from a 2-year cohort study of community-dwelling elderly Japanese people.
Participants were 743 community-dwelling elderly Japanese people aged 65 years or older. We used bioelectrical impedance analysis (BIA) to measure muscle mass, grip strength to measure muscle strength, and usual walking speed to measure physical performance in a baseline study. Functional disability was defined using an activities of daily living (ADL) scale and instrumental activities of daily living (IADL) scale at baseline and during follow-up examinations 2 years later. Logistic regression analysis, adjusted for age and body mass index, was used to examine the association between sarcopenia and the occurrence of functional disability.
In the present study, 7.8% of men and 10.2% of women were classified as having sarcopenia. Among sarcopenia patients in the baseline study, 36.8% of men and 18.8% of women became dependent in ADL at 2-year follow up. From the logistic regression analysis adjusted by age and body mass index, sarcopenia was significantly associated with the occurrences of physical disability compared with normal subjects in both men and women.
Sarcopenia, defined by muscle mass, muscle strength and physical performance, was associated with functional decline over a 2-year period in elderly Japanese. Interventions to prevent sarcopenia are very important to prevent functional decline among elderly individuals.
本研究旨在通过对日本社区居住的老年人群进行为期 2 年的队列研究，确定由肌肉质量、肌肉力量和身体表现定义的肌少症与功能障碍之间的关系。
参与者为 743 名年龄在 65 岁或以上的社区居住的日本老年人。我们在基线研究中使用生物电阻抗分析（BIA）测量肌肉质量，使用握力测量肌肉力量，使用常规步行速度测量身体表现。在基线和 2 年后的随访检查中，使用日常生活活动（ADL）量表和工具性日常生活活动（IADL）量表来定义功能障碍。使用逻辑回归分析，调整年龄和体重指数，来检查肌少症与功能障碍发生之间的关联。
在本研究中，7.8%的男性和 10.2%的女性被归类为患有肌少症。在基线研究中患有肌少症的患者中，36.8%的男性和 18.8%的女性在 2 年随访时出现 ADL 依赖。从调整年龄和体重指数的逻辑回归分析中，肌少症与男性和女性的正常受试者相比，与身体残疾的发生显著相关。
由肌肉质量、肌肉力量和身体表现定义的肌少症与日本老年人在 2 年内的功能下降有关。预防肌少症的干预措施对于预防老年人的功能下降非常重要。
