Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Innsbruck Medical University, Innsbruck, Austria.
Clin Transplant. 2013 Mar-Apr;27(2):E81-90. doi: 10.1111/ctr.12086. Epub 2013 Mar 3.
Over 70 hands and 20 faces have been transplanted during the past 13 yr, which have shown good to excellent functional and esthetic outcomes. However, (skin) rejection episodes complicate the post-operative courses of hand and face transplant recipients and are still a major obstacle to overcome after reconstructive allotransplantation. This article summarizes all relevant information on the skin component and rejection of a vascularized composite allograft. As more and more centers plan to implement a vascularized composite allotransplantation (VCA) program, we further develop guidelines and recommendations on collection and processing of skin biopsies from hand and face allograft recipients. This will help to standardize post-operative monitoring, avoid pitfalls for those new in the field and facilitate comparison of data on VCA between centers.
在过去的 13 年中，已经进行了超过 70 次手部和 20 次面部移植，这些移植显示出了良好到极好的功能和美学效果。然而，（皮肤）排斥反应使手部和面部移植受者的术后过程复杂化，并且仍然是重建同种异体移植后需要克服的主要障碍。本文总结了所有关于血管化复合同种异体移植物的皮肤成分和排斥反应的相关信息。随着越来越多的中心计划实施血管化复合同种异体移植（VCA）项目，我们进一步制定了从手部和面部同种异体移植物受者采集和处理皮肤活检的指南和建议。这将有助于规范术后监测，避免该领域新手的陷阱，并促进中心之间 VCA 数据的比较。
