Center for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
Transpl Int. 2011 Aug;24(8):760-9. doi: 10.1111/j.1432-2277.2011.01261.x. Epub 2011 May 9.
Overall, more than 60 hand/forearm/arm transplantations and 16 face transplantations have been performed in the past 12 years. In the European experience summarized here, three grafts have been lost in response to a vascular thrombosis (n = 1), rejection and incompliance with immunosuppression (n = 1) and death (n = 1). The overall functional and esthetic outcome is very satisfactory, but serious side effects and complications related to immunosuppression are challenges hindering progress in this field. The high levels of immunosuppression, skin rejection, nerve regeneration, donor legislation and the acceptance level need to be addressed to promote growth of this promising new field in transplantation and reconstructive surgery.
总体而言，过去 12 年中已经进行了超过 60 例手部/前臂/手臂移植和 16 例面部移植。在本文总结的欧洲经验中，有 3 例因血管血栓形成（n = 1）、排斥反应和免疫抑制不依从（n = 1）以及死亡（n = 1）而导致移植物丢失。整体功能和美观效果非常令人满意，但与免疫抑制相关的严重副作用和并发症是阻碍该领域进展的挑战。需要解决高水平的免疫抑制、皮肤排斥、神经再生、供体立法和接受程度问题，以促进移植和重建外科领域这一充满希望的新领域的发展。
