二尖瓣病变合并心房颤动患者心房重构中的细胞内乳酸信号级联反应
Intracellular lactate signaling cascade in atrial remodeling of mitral valvular patients with atrial fibrillation.
作者信息
Xu Jing, Xu Xiaohan, Si Linjie, Xue Lei, Zhang Shijiang, Qin Jianwei, Wu Yanhu, Shao Yongfeng, Chen Yijiang, Wang Xiaowei
机构信息
Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
出版信息
J Cardiothorac Surg. 2013 Mar 1;8:34. doi: 10.1186/1749-8090-8-34.
BACKGROUND
Atrial remodeling has emerged as the structural basis for the maintenance and recurrence of atrial fibrillation. Lactate signaling cascade was recently linked to some cardiovascular disorders for its regulatory functions to myocardial structural remodeling. It was hypothesized that lactate signaling cascade was involved in the maintenance and recurrence of atrial fibrillation by regulating atrial structural remodeling.
METHODS
Biopsies of right atrial appendage and clinical data were collected from sex- and age-matched 30 persistent atrial fibrillation, 30 paroxysmal atrial fibrillation, 30 sinus rhythm patients undergoing isolated mitral valve surgery and 10 healthy heart donors.
RESULTS
Atrial fibrillation groups had higher atrial lactate expression and this upregulated expression was positively correlated with regulatory indicators of atrial structural remodeling as reflected by severe oxidative stress injury and mitochondrial control of apoptosis.
CONCLUSIONS
The present findings suggest a potential role for lactate signaling cascade in the maintenance and recurrence of atrial fibrillation and possibly represent new targets for therapeutic intervention in this disorder.
背景
心房重构已成为心房颤动维持和复发的结构基础。乳酸信号级联最近因其对心肌结构重构的调节功能而与一些心血管疾病相关联。据推测，乳酸信号级联通过调节心房结构重构参与心房颤动的维持和复发。
方法
收集30例持续性心房颤动、30例阵发性心房颤动、30例接受单纯二尖瓣手术的窦性心律患者以及10名健康心脏供体的右心耳活检组织和临床资料，这些患者和供体在性别和年龄上相匹配。
结果
心房颤动组心房乳酸表达较高，这种上调表达与心房结构重构的调节指标呈正相关，严重氧化应激损伤和线粒体对凋亡的控制反映了这一点。
结论
目前的研究结果表明乳酸信号级联在心房颤动的维持和复发中具有潜在作用，可能代表了这种疾病治疗干预的新靶点。
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