Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, United States.
Reprod Toxicol. 2013 Apr;36:104-16. doi: 10.1016/j.reprotox.2012.11.011. Epub 2013 Jan 25.
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures.
环境化合物已被证明可促进疾病的表观遗传跨代遗传。本研究旨在确定涉及喷气燃料 (JP-8) 的碳氢混合物是否会促进疾病的表观遗传跨代遗传。处于生殖期的 F0 代雌性大鼠在胎儿性腺发育期受到短暂暴露。直接暴露的 F1 代雄性和雌性的肾脏异常、前列腺和青春期异常的发生率增加，雌性的原始卵泡丢失和多囊卵巢疾病的发生率增加。第一代跨代是 F3 代，喷气燃料系的雌性原始卵泡丢失和多囊卵巢疾病以及雌性和雄性肥胖的发生率增加。对喷气燃料系 F3 代精子表观基因组的分析确定了 33 个差异 DNA 甲基化区域，称为表观突变。这些观察结果表明，碳氢化合物可促进疾病的表观遗传跨代遗传和精子表观突变，这可能是祖先暴露的生物标志物。
