Department of Oral Pathology, 9th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):368-75. doi: 10.1016/j.oooo.2012.11.018.
The aim of this study was to analyze the clinicopathologic characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck (ACCHN).
This was a retrospective study of 218 patients with ACCHN.
The cohort included 110 men and 108 women; the parotid and the palate were the most common site of involvement. Of 203 patients with follow-up information (range 2-132 months), 57 had died of the tumor. Distant metastasis (DM) and local recurrence (LR) were documented in 83 (40.9%) and 34 (16.7%) patients, respectively. Cox regression analysis indicated that a solid pattern was a marker for LR and that positive margins and older age were risk factors for DM. Histologic pattern, T stage, N stage, LR, DM, and patient age contributed to the prediction of disease-specific survival.
A solid pattern, metastasis, LR, and older age are the most important factors for predicting poor prognosis in Chinese patients with ACCHN.
本研究旨在分析头颈部腺样囊性癌（ACCHN）的临床病理特征和预后因素。
这是一项对 218 例 ACCHN 患者的回顾性研究。
该队列包括 110 名男性和 108 名女性；最常见的发病部位是腮腺和腭部。203 例有随访信息（范围 2-132 个月）的患者中，57 例死于肿瘤。83 例（40.9%）患者发生远处转移（DM），34 例（16.7%）患者发生局部复发（LR）。Cox 回归分析表明，实性模式是 LR 的标志，阳性切缘和年龄较大是 DM 的危险因素。组织学模式、T 分期、N 分期、LR、DM 和患者年龄是预测疾病特异性生存的重要因素。
实性模式、转移、LR 和年龄较大是预测中国 ACCHN 患者预后不良的最重要因素。
