Department of Medical Biophysics, University of Toronto, Toronto, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada.
Ultrasound Med Biol. 2013 Jun;39(6):950-5. doi: 10.1016/j.ultrasmedbio.2012.12.011. Epub 2013 Feb 27.
This study assessed the reproducibility of shear wave elastography (SWE) in the liver of healthy volunteers. Intra- and inter-operator reliability and repeatability were quantified in three different liver segments in a sample of 15 subjects, scanned during four independent sessions (two scans on day 1, two scans 1 wk later) by two operators. A total of 1440 measurements were made. Reproducibility was assessed using the intra-class correlation coefficient (ICC) and a repeated measures analysis of variance. The shear wave speed was measured and used to estimate Young's modulus using the Supersonics Imagine Aixplorer. The median Young's modulus measured through the inter-costal space was 5.55 ± 0.74 kPa. The intra-operator reliability was better for same-day evaluations (ICC = 0.91) than the inter-operator reliability (ICC = 0.78). Intra-observer agreement decreased when scans were repeated on a different day. Inter-session repeatability was between 3.3% and 9.9% for intra-day repeated scans, compared with to 6.5%-12% for inter-day repeated scans. No significant difference was observed in subjects with a body mass index greater or less than 25 kg/m(2).
本研究评估了剪切波弹性成像（SWE）在健康志愿者肝脏中的可重复性。在 15 名受试者的样本中，在三个不同的肝段中进行了定量研究，由两名操作员在四个独立的时间段内（第一天进行两次扫描，一周后进行两次扫描）进行扫描。共进行了 1440 次测量。使用组内相关系数（ICC）和重复测量方差分析评估了可重复性。测量剪切波速度，并使用 Supersonics Imagine Aixplorer 估计杨氏模量。通过肋间隙测量的杨氏模量中位数为 5.55 ± 0.74 kPa。同天评估的内操作员可靠性（ICC=0.91）优于外操作员可靠性（ICC=0.78）。当在不同的日子重复扫描时，观察者内的一致性降低。对于日内重复扫描，组内重复性在 3.3%至 9.9%之间，而对于日间重复扫描，组内重复性在 6.5%-12%之间。在体重指数大于或小于 25 kg/m2 的受试者中，未观察到显著差异。
