Department of Pathology and Laboratory Medicine, Ralph H. Johnson VAMC, USA.
Blood Cells Mol Dis. 2013 Jun;51(1):3-8. doi: 10.1016/j.bcmd.2013.01.008. Epub 2013 Feb 27.
Over a decade ago, several preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability (often referred to as HSC plasticity) of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired in controversy and remained dormant for almost a decade. This commentary provides a concise review of evidence for HSC plasticity, including more recent findings based on single HSC transplantation in mouse and clinical transplantation studies. There is strong evidence for the concept that HSCs are pluripotent and are the source for the majority, if not all, of the cell types in our body. Also discussed are some biological and experimental issues that need to be considered in the future investigation of HSC plasticity.
十多年前，几项临床前移植研究提出了造血干细胞（HSCs）具有组织重建能力（通常称为 HSC 可塑性）的惊人概念。虽然这为许多器官和组织疾病的激进新疗法开辟了一个令人兴奋的时代，但该概念很快陷入争议，并在近十年中一直处于休眠状态。本评论提供了对 HSC 可塑性证据的简要回顾，包括基于小鼠单个 HSC 移植和临床移植研究的最新发现。有强有力的证据表明，HSCs 具有多能性，是我们体内大多数（如果不是全部）细胞类型的来源。本文还讨论了在未来对 HSC 可塑性的研究中需要考虑的一些生物学和实验问题。
