Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Epidemiology of Occupational and Social Determinants of Health Team, F-94807 Villejuif, France.
Cancer Epidemiol. 2013 Jun;37(3):284-9. doi: 10.1016/j.canep.2013.02.001. Epub 2013 Feb 28.
Results on the relationship between coffee and tea drinking and the risk of oral cavity cancer are contrasted. The aim of this study was to evaluate the relation between coffee and tea drinking and the risk of oral cavity cancer in France, a high incidence area.
We conducted a population based case-control study with face-to-face interviews and standardized questionnaires (the ICARE study, Investigation of occupational and environmental causes of respiratory cancers). We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls. Odds-ratios (ORs) and 95% confidence intervals (95% CI) associated with tea and coffee consumption (quantity, duration, cumulative consumption) were estimated by unconditional logistic regression with adjustment for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking.
We observed inverse associations between oral cavity cancer and tea or coffee consumption (odds ratio, 0.39; 95% CI 0.21-0.70, for the highest quartile of tea consumption, and 0.60, 95% CI 0.34-1.05, for the highest quartile of coffee consumption). Exclusive tea or coffee consumption was associated with a reduced risk of oral cavity cancer and their joint effect was multiplicative. No differences in risk between men and women or between consumers of tobacco and alcohol and non-consumers were observed. The odds ratios related to the subsites usually included in the oropharynx (soft palate and base of the tongue) did not differ significantly from that observed for the other subsites of the oral cavity.
Tea and coffee drinking may decrease the risk of oral cavity cancer through antioxidant components which play a role in the repair of cellular damages. These findings need further investigation in prospective studies and the underlying mechanisms in humans remain to be clarified.
对咖啡和茶饮用与口腔癌风险之间的关系进行了对比。本研究旨在评估法国这一高发地区咖啡和茶饮用与口腔癌风险之间的关系。
我们开展了一项基于人群的病例对照研究，采用面对面访谈和标准化问卷（ICARE 研究，对呼吸道癌症的职业和环境病因的调查）。我们使用了 689 例口腔鳞状细胞癌病例和 3481 例对照的数据。通过非条件逻辑回归，调整年龄、性别、居住地、教育程度、体重指数、吸烟和饮酒等因素，估计了与茶和咖啡消费（数量、持续时间、累积消费）相关的比值比（OR）和 95%置信区间（95%CI）。
我们观察到口腔癌与茶或咖啡消费之间呈负相关（最高四分位茶消费的比值比为 0.39，95%CI 0.21-0.70，最高四分位咖啡消费的比值比为 0.60，95%CI 0.34-1.05）。独家茶或咖啡消费与口腔癌风险降低相关，其联合效应呈乘法关系。在男性和女性之间，或在吸烟和饮酒的消费者与非消费者之间，风险没有差异。与通常包含在口咽部（软腭和舌根）的亚部位相关的比值比与观察到的其他口腔亚部位的比值比没有显著差异。
茶和咖啡的饮用可能通过抗氧化成分降低口腔癌的风险，这些成分在细胞损伤修复中发挥作用。这些发现需要在前瞻性研究中进一步调查，并且人类的潜在机制仍需阐明。
