Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania, Italy.
Chemosphere. 2013 May;91(6):791-6. doi: 10.1016/j.chemosphere.2013.01.091. Epub 2013 Feb 28.
Polychlorinated biphenyls (PCBs) are organic pollutants with lipophilic properties, due to their persistence, they are present in environment at potentially dangerous concentrations for humans health. In this work we investigated the interaction and absorption of 2,4,4'-trichlorobiphenyl (PCB 28), 2,3,3',4,4'-pentachlorobiphenyl (PCB 105) and 2,3,3',4,4',5,5'-eptachlorobiphenyl (PCB 189) with dimyristoylphosphatidylcholine (DMPC) multilamellar vesicles (MLV), chosen as biomembrane models, by differential scanning calorimetry technique (DSC). The obtained results indicate that the tested compounds affected the thermotropic behaviour of MLV to different degree, modifying the phase transition peak and shifting it towards lower temperature. The effect of an aqueous or lipophilic medium on the absorption process of these compounds by the biomembrane models was also investigated revealing that the process is hindered by the aqueous medium but favoured by the lipophilic medium.
多氯联苯（PCBs）是具有亲脂性的有机污染物，由于其持久性，它们以对人类健康构成潜在危险的浓度存在于环境中。在这项工作中，我们通过差示扫描量热法（DSC）研究了 2,4,4'-三氯联苯（PCB 28）、2,3,3',4,4'-五氯联苯（PCB 105）和 2,3,3',4,4',5,5'-七氯联苯（PCB 189）与二肉豆蔻酰磷脂酰胆碱（DMPC）多层层状囊泡（MLV）的相互作用和吸收，MLV 被选为生物膜模型。所得结果表明，测试化合物不同程度地影响了 MLV 的热致行为，改变了相变峰并将其移向低温。还研究了水相或亲脂相介质对这些化合物被生物膜模型吸收过程的影响，结果表明，水相介质阻碍了该过程，而亲脂相介质有利于该过程。
