Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy.
Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, CZ 88100, Italy.
Environ Toxicol Pharmacol. 2015 May;39(3):1154-60. doi: 10.1016/j.etap.2015.04.002. Epub 2015 Apr 13.
The presence of polybrominated flame retardants in the environment seems to be increasing in the past decade. Considering the toxic effects of these pollutants, it is important evaluating the potential interaction with biological membranes for a risk assessment. In this study low and high brominated biphenyls and biphenyl ethers were used to investigate their interaction with biological membrane models constituted by liposomes, using differential scanning calorimetry (DSC) technique. The medium influence on membrane absorption was also assessed. The findings indicate that membrane interaction is controlled by compound structural characteristics. The membrane absorption is allowed by lipophilic medium; instead hydrophilic medium prevents membrane permeation.
在过去十年中，环境中多溴阻燃剂的存在似乎呈上升趋势。考虑到这些污染物的毒性作用，评估其与生物膜的潜在相互作用以进行风险评估是很重要的。在这项研究中，使用低溴和高溴二苯并噁嗪和二苯醚来研究它们与由脂质体组成的生物膜模型的相互作用，使用差示扫描量热法（DSC）技术。还评估了介质对膜吸收的影响。研究结果表明，膜相互作用受化合物结构特征的控制。亲脂性介质允许膜吸收；而亲水性介质则阻止膜渗透。
