Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.
J Affect Disord. 2013 Sep 5;150(2):522-6. doi: 10.1016/j.jad.2013.01.023. Epub 2013 Mar 1.
Attachment is associated both with the risk of developing a mood disorder and temperamental profile. Relatively little is known about these associations in children of a parent with bipolar disorder (BD). The present study is a preliminary analysis of the association between attachment, temperament and psychopathology among high-risk offspring.
As part of an ongoing prospective cohort study, offspring from families with one parent with BD (HR) and offspring from families with unaffected parents (C) were clinically assessed using KSADS-PL format interviews annually. Validated self-report measures of perceived attachment and temperament were completed.
Perceived attachment did not differentiate HR from C offspring and did not predict psychopathology or mood disorder in particular. However, high emotionality significantly predicted the risk of psychopathology in HR offspring, where 1 standard deviation increase in emotionality significantly increased the hazard of psychopathology by a factor of 1.36 (p=0.0009) and mood disorder by a factor of 1.24 (p=0.02).
Use of retrospective measures and low sample size for some models.
There may be no gross abnormalities in attachment among HR compared to C offspring. It remains unclear if emotionality is a barometer of illness or a true risk factor in this population. More longitudinal research is needed to advance understanding of the influential pathways by which psychosocial risk factors impact the development of BD. This research has implications for targeted early interventions in HR youth.
依恋既与发生情绪障碍的风险有关,也与气质特征有关。在患有双相情感障碍 (BD) 的父母的子女中,人们对这些关联知之甚少。本研究初步分析了高危子女中依恋、气质和精神病理学之间的关系。
作为一项正在进行的前瞻性队列研究的一部分,使用 KSADS-PL 格式访谈每年对父母一方患有 BD(HR)的子女和父母一方未受影响的子女(C)进行临床评估。完成了经过验证的依恋和气质自评量表。
感知依恋并未将 HR 与 C 后代区分开来,也未特别预测精神病理学或心境障碍。然而,高情绪性显著预测了 HR 后代的精神病理学风险,情绪性增加 1 个标准差会使精神病理学的风险增加 1.36 倍(p=0.0009),心境障碍的风险增加 1.24 倍(p=0.02)。
一些模型使用回顾性测量和小样本量。
与 C 后代相比,HR 中依恋可能没有明显异常。情绪性是否是该人群中疾病的晴雨表或真正的风险因素仍不清楚。需要更多的纵向研究来深入了解心理社会风险因素影响 BD 发展的影响途径。这项研究对 HR 青少年的针对性早期干预具有重要意义。