Department of Bioanalysis, Laboratory of Food Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Toxicol Lett. 2013 Apr 26;218(3):281-92. doi: 10.1016/j.toxlet.2013.02.016. Epub 2013 Feb 28.
In the present study, a quantitative dietary exposure assessment of mycotoxins and their masked forms was conducted on a national representative sample of the Belgian population using the contamination data of cereal-based foods. Cereal-based food products (n=174) were analysed for the occurrence of deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, zearalenone, α-zearalenol, β-zearalenol, T-2-toxin, HT-2-toxin, and their respective masked forms, including, deoxynivalenol-3-glucoside, zearalenone-4-glucoside, α-zearalenol-4-glucoside, β-zearalenol-4-glucoside and zearalenone-4-sulfate. Fibre-enriched bread, bran-enriched bread, breakfast cereals, popcorn and oatmeal were collected in Belgian supermarkets according to a structured sampling plan and analysed during the period from April 2010 to October 2011. The habitual intake of these food groups was estimated from a national representative food intake survey. According to a probabilistic exposure analysis, the mean (and P95) mycotoxin intake for the sum of the deoxynivalenol-equivalents, zearalenone-equivalents, and the sum of HT-2-and T-2-toxin for all cereal-based foods was 0.1162 (0.4047, P95), 0.0447 (0.1568, P95) and 0.0258 (0.0924, P95) μg kg(-1)body weight day(-1), respectively. These values were below the tolerable daily intake (TDI) levels for deoxynivalenol, zearalenone and the sum of T-2 and HT-2 toxin (1.0, 0.25 and 0.1 μg kg(-1)body weight day(-1), respectively). The absolute level exceeding the TDI for all cereal-based foods was calculated, and recorded 0.85%, 2.75% and 4.11% of the Belgian population, respectively.
在本研究中，采用基于谷物的食品污染数据，对比利时代表性人群进行了霉菌毒素及其掩蔽形式的定量膳食暴露评估。对 174 种基于谷物的食品进行了脱氧雪腐镰刀菌烯醇、3-乙酰脱氧雪腐镰刀菌烯醇、15-乙酰脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮、α-玉米赤霉烯醇、β-玉米赤霉烯醇、T-2 毒素、HT-2 毒素及其各自掩蔽形式（包括脱氧雪腐镰刀菌烯醇-3-葡萄糖苷、玉米赤霉烯酮-4-葡萄糖苷、α-玉米赤霉烯醇-4-葡萄糖苷、β-玉米赤霉烯醇-4-葡萄糖苷和玉米赤霉烯酮-4-硫酸盐）的检测。按照结构化抽样计划，在比利时超市采集了富含纤维的面包、麸皮面包、早餐麦片、爆米花和燕麦片，并于 2010 年 4 月至 2011 年 10 月期间进行了分析。这些食物组的习惯性摄入量是根据全国代表性的食物摄入量调查来估计的。根据概率性暴露分析，对于所有基于谷物的食品中脱氧雪腐镰刀菌烯醇当量、玉米赤霉烯酮当量和 HT-2 和 T-2 毒素总和的平均（和 P95）摄入量为 0.1162（0.4047，P95）、0.0447（0.1568，P95）和 0.0258（0.0924，P95）μg kg(-1)体重日(-1)。这些值低于脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮和 T-2 和 HT-2 毒素总和的可耐受日摄入量（TDI）水平（分别为 1.0、0.25 和 0.1μg kg(-1)体重日(-1)）。对于所有基于谷物的食品，计算了超过 TDI 的绝对值，并记录了分别为 0.85%、2.75%和 4.11%的比利时人口。
