Department of Society, Human Development, and Health, Harvard School of Public Health, 677 Huntington Avenue, Kresge 617, Boston, MA 02115, USA.
Health Place. 2013 May;21:133-9. doi: 10.1016/j.healthplace.2012.12.008. Epub 2013 Feb 4.
Prior research found that Americans born in 6 southeastern states (the AF-risk zone) had elevated risk of AF-related mortality, but no mechanisms were identified. We hypothesized the association between AF-related mortality and AF-risk zone birth is explained by indicators of childhood social disadvantage or adult risk factors. In 24,323 participants in the US Health and Retirement Study, we found that birth in the AF-risk zone was significantly associated with hazard of AF-related mortality. Among whites, the relationship was specific to place of birth, rather than place of adult residence. Neither paternal education nor subjectively assessed childhood SES predicted AF-related mortality. Conventional childhood and adult cardiovascular risk factors did not explain the association between place of birth and AF-related mortality.
先前的研究发现，出生于东南部 6 个州（AF 风险区）的美国人患与房颤相关的死亡率风险增加，但未确定具体机制。我们假设，与房颤相关的死亡率和 AF 风险区出生之间的关联可以用儿童社会劣势或成人危险因素的指标来解释。在美国健康与退休研究中，我们在 24323 名参与者中发现，出生在 AF 风险区与房颤相关的死亡率的发生风险显著相关。在白人中，这种关系是特定于出生地的，而不是成年居住地。父亲的教育程度和主观评估的儿童社会经济地位都不能预测与房颤相关的死亡率。传统的儿童和成人心血管危险因素并不能解释出生地与房颤相关死亡率之间的关联。
