Lee Doo Jae, Kang Sang Won
Division of Life and Pharmaceutical Sciences and Research Center for Cellular Homeostasis, Ewha Womans University, Seoul 120-750, Korea.
Mol Cells. 2013 Feb;35(2):93-8. doi: 10.1007/s10059-013-0034-9. Epub 2013 Feb 21.
The migration and invasion of cancer cells are the first steps in metastasis. Through a series of cellular responses, including cytoskeletal reorganization and degradation of the extracellular matrix, cancer cells are able to separate from the primary tumor and metastasize to distant locations in the body. In cancer cells, reactive oxygen species (ROS) play important roles in the migration and invasion of cells. Stimulation of cell surface receptors with growth factors and integrin assembly generates ROS, which relay signals from the cell surface to important signaling proteins. ROS then act within cells to promote migration and invasion. In this review, we collect recent evidence pointing towards the involvement of ROS in tumor metastasis and discuss the roles of ROS at different stages during the process of cancer cell migration, invasion and epithelial-mesenchymal transition.
癌细胞的迁移和侵袭是转移的第一步。通过一系列细胞反应，包括细胞骨架重组和细胞外基质降解，癌细胞能够从原发肿瘤分离并转移至身体的远处部位。在癌细胞中，活性氧（ROS）在细胞的迁移和侵袭中发挥重要作用。生长因子刺激细胞表面受体以及整合素组装会产生活性氧，活性氧将信号从细胞表面传递至重要的信号蛋白。然后，活性氧在细胞内发挥作用以促进迁移和侵袭。在本综述中，我们收集了近期表明活性氧参与肿瘤转移的证据，并讨论了活性氧在癌细胞迁移、侵袭和上皮-间质转化过程中不同阶段的作用。
