Zhang An-Ping, Liu Bao-Hua, Wang Li, Gao Yu, Li Fan, Sun Su-Xia
Department of General Surgery, Third Military Medical University, Guangzhou, China.
Asian Pac J Cancer Prev. 2011;12(12):3421-5.
The potential role of GSTM1, GSTT1 and GSTP1 polymorphisms in risk of gastric cancer in Chinese was studied.
We collected 194 gastric cancers by pathologic examination and 412 controls from southern China during January 2007 to January 2011. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method.
Individuals carrying null GSTM1 and GSTT1 had 1.49 and 1.96 fold risk sof gastric cancer when compared with respective non-null genotypes. We also found a non-significant 37% excess risk of gastric cancer among carriers of GSTP1 1b/1b genotype when compared with 1a/1a genotype (OR=1.37, 95% CI=0.81-2.25). The combination of null/null GSTM1 and GSTT1 genotypes showed higher increased risk of gastric cancer (OR=3.17, 95% CI=1.68-4.21). Moreover, cancers in ever smokers and ever drinkers were observed to be strongly associated with null GSTM1 and GSTT1, and a significant cancer risk was observed in positive H.pylori infection individuals with null GSTT1.
Our study provided evidence that genetic deletion of GSTM1 and GSTT1 may contribute to increased susceptibility to gastric cancer in our Chinese population, while the GSTP1a/b polymorphism may not.
研究谷胱甘肽硫转移酶M1（GSTM1）、谷胱甘肽硫转移酶T1（GSTT1）和谷胱甘肽硫转移酶P1（GSTP1）基因多态性在中国胃癌发生风险中的潜在作用。
2007年1月至2011年1月期间，我们通过病理检查收集了来自中国南方的194例胃癌患者及412名对照者。采用聚合酶链反应-反向点杂交法（PCR-CTPP）进行基因分型。
与各自的非缺失基因型相比，携带GSTM1和GSTT1基因缺失的个体患胃癌的风险分别增加了1.49倍和1.96倍。我们还发现，与GSTP1 1a/1a基因型相比，GSTP1 1b/1b基因型携带者患胃癌的风险有37%的增加，但差异无统计学意义（比值比[OR]=1.37，95%可信区间[CI]=0.81-2.25）。GSTM1和GSTT1基因缺失/缺失基因型的组合显示患胃癌的风险增加更高（OR=3.17，95%CI=1.68-4.21）。此外，观察到曾经吸烟者和曾经饮酒者患癌与GSTM1和GSTT1基因缺失密切相关，并且在幽门螺杆菌感染阳性且GSTT1基因缺失的个体中观察到显著的患癌风险。
我们的研究提供了证据，表明GSTM1和GSTT1基因的缺失可能导致中国人群患胃癌的易感性增加，而GSTP1 a/b基因多态性可能并非如此。
