Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Am J Perinatol. 2014 Jan;31(1):69-76. doi: 10.1055/s-0033-1334451. Epub 2013 Mar 1.
To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).
We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.
GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.
We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.
确定与葡萄糖稳态相关的遗传变异是否与妊娠糖尿病（GDM）相关。
我们对妊娠、感染和营养（PIN）研究队列中的 899 名自我认定的白种人和 386 名自我认定的非裔美国人进行了基因分型，以确定与 II 型糖尿病（T2DM）和/或欧洲人群葡萄糖稳态相关的 38 个单核苷酸多态性（SNP）。
在 899 名白种人和 386 名非裔美国妇女中，56 名（6.2%）白人妇女和 24 名（6.2%）非裔美国妇女被诊断为 GDM。在白种妇女中，GDM 与 TCF7L2 rs7901695、MTNR1B rs10830963 和 GCKR rs780094 等位基因的携带有关，这些等位基因与非妊娠人群中的 T2DM 和空腹血糖有关。在非裔美国参与者中，我们发现 TSPAN8 rs7961581 C 等位基因纯合子的风险增加，而 JAZF1 rs864745 T 等位基因携带者的风险降低。
我们在 PIN 队列中发现了几个与 GDM 风险相关的 SNP。母体基因分型可能可以识别出有妊娠葡萄糖耐量受损风险的女性。
