Takishima T, Machida K, Honda N, Mamiya T, Takahashi T, Kamano T, Tamaki S
Department of Radiology, Saitama Medical Center, Saitama Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1991 Jan 25;51(1):66-73.
In an attempt to determine the normal evolution of N-isopropyl p-I-123-iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT), we selected 12 children (an age range of 1 month-3 year) who were diagnosed as normal in follow-up between 6 month-3 year by neurological examination, X-ray computed tomography, electroencephalography and 123I-IMP SPECT in our 78 cases. SPECT of the brain was performed 30 minutes after intravenous administration of 74 MBq (2 mCi) 123I-IMP using a rotating gamma camera equipped with a 30-degree slant-hole collimator. In neonates, a predominant activity was observed in the basal ganglia and thalamus, with only slight parietal and occipital activity. Frontal cortex was barely recognizable. Under 1 year, cortical activity was gradually increased and clearly visible. After 1 year, SPECT images were similar to those of adult. In conclusion there was an important modification of the regional perfusion pattern in relation to brain maturation.
为了确定 N-异丙基-p-I-123-碘安非他明（123I-IMP）单光子发射计算机断层扫描（SPECT）的正常演变情况，我们从 78 例病例中挑选出 12 名儿童（年龄范围为 1 个月至 3 岁），这些儿童在 6 个月至 3 岁期间通过神经学检查、X 射线计算机断层扫描、脑电图和 123I-IMP SPECT 随访诊断为正常。静脉注射 74 MBq（2 mCi）123I-IMP 30 分钟后，使用配备 30 度斜孔准直器的旋转伽马相机进行脑部 SPECT 检查。在新生儿中，基底神经节和丘脑观察到主要活性，顶叶和枕叶只有轻微活性。额叶皮质几乎无法辨认。1 岁以下，皮质活性逐渐增加且清晰可见。1 岁以后，SPECT 图像与成人相似。总之，区域灌注模式与脑成熟有关，存在重要变化。
