Newberne P M, Bueche D, Riengropitak S, Schrager T F
Department of Pathology, Boston University School of Medicine, MA 02118.
Nutr Cancer. 1990;13(4):235-42. doi: 10.1080/01635589009514065.
Rats fed diets high (24%) or low (5%) in fat were given dietary levels of vitamin A (retinyl acetate) ranging from 0.3 to 30 micrograms/g food. The lowest tumor incidence was in the group fed diets high in vitamin A and low in fat. When the diet was high in fat and low in vitamin A, tumor incidence and frequency were significantly increased over that in rats fed the high-fat diet with normal levels of vitamin A (10 micrograms/g feed). However, even with a high level of fat in the diet, raising the level of vitamin A above 10 micrograms/g feed had no further beneficial effect. Thus, although there was a significant interaction between vitamin A and fat, it is the latter that appears to require the most attention, once the vitamin A intake is adequate. These data support the view that we should set as a goal an adequate, diversified diet that is low in fat but that an excessive intake of vitamins such as vitamin A that are toxic should be avoided.
给食用高脂肪（24%）或低脂肪（5%）饮食的大鼠喂食维生素A（醋酸视黄酯）水平为0.3至30微克/克食物的日粮。肿瘤发生率最低的是喂食高维生素A和低脂肪日粮的组。当饮食中脂肪含量高而维生素A含量低时，与喂食正常维生素A水平（10微克/克饲料）的高脂肪日粮的大鼠相比，肿瘤发生率和发生频率显著增加。然而，即使饮食中脂肪含量高，将维生素A水平提高到10微克/克饲料以上也没有进一步的有益效果。因此，尽管维生素A和脂肪之间存在显著的相互作用，但一旦维生素A摄入量充足，似乎脂肪更需要关注。这些数据支持这样一种观点，即我们应该将目标设定为一种充足、多样化且低脂肪的饮食，但应避免过量摄入有毒的维生素，如维生素A。
